Predicting potential drug-drug interactions by integrating chemical, biological, phenotypic and network data

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• 作者：Wen Zhang ; Yanlin Chen ; Feng Liu ; Fei Luo ; Gang Tian ; Xiaohong Li
• 关键词：Drug ; drug interaction ; Ensemble learning ; Missing link prediction ; Random walk
• 刊名：BMC Bioinformatics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：637KB
• 刊物主题：Bioinformatics; Microarrays; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Algorithms;
• 出版者：BioMed Central
• ISSN：1471-2105
• 卷排序：18

文摘

BackgroundDrug-drug interactions (DDIs) are one of the major concerns in drug discovery. Accurate prediction of potential DDIs can help to reduce unexpected interactions in the entire lifecycle of drugs, and are important for the drug safety surveillance.