An Unusual Cause of Fever, Generalized Lymphadenopathy and Eosinophilia in a HCV-Positive 6-Year-Old Boy

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• 作者：Rajesh Kumar ; Prashant Sharma ; Pranab Dey…
• 关键词：Bone marrow examination ; Disseminated histoplasmosis ; Eosinophilia ; Fungal infection ; Hepatitis C ; Lymphadenopathy
• 刊名：Indian Journal of Hematology and Blood Transfusion
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：33
• 期：1
• 页码：130-132
• 全文大小：
• 刊物主题：Hematology; Oncology; Blood Transfusion Medicine; Human Genetics;
• 出版者：Springer India
• ISSN：0974-0449
• 卷排序：33

文摘

A 6-year-old boy presented with a 3-month history of high-grade fever and night-sweats but without chills/rigors. On examination, he had moderate hepatosplenomegaly with multiple enlarged cervical and axillary lymph nodes. His hemogram revealed anemia and marked eosinophilia. Initial investigations were negative, except anti-HCV IgG antibodies, that were positive. Bone marrow aspirate showed a single histiocyte containing suspicious intracellular yeast-like forms. Cervical lymph node aspiration revealed a heavy load of intra- and extra-cellular Histoplasma spp. Disseminated histoplasmosis remains an unusual cause of peripheral eosinophilia and diagnosis can often be rendered fairly easily by cytomorphological evaluation. The case illustrates how Indian pathologists must maintain a high index of suspicion for unexpected infectious disorders in cases with eosinophilia.