Acute hypoglycemic and antihyperglycemic effects of ten Sri Lankan medicinal plant extracts in healthy and streptozotocin induced diabetic rats

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• 作者：Anoja Priyadarshani Attanayake…
• 关键词：Animal ; Ethnopharmacology ; Glucose tolerance test ; Streptozotocin
• 刊名：International Journal of Diabetes in Developing Countries
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：35
• 期：3
• 页码：177-183
• 全文大小：173 KB
• 参考文献：1.Katulanda P, Sheriff MH, Matthews DR. The diabetes epidemic in Sri Lanka - a growing problem. Ceylon Med J. 2006;51:26–8.PubMed
  2.Macedo CS, Capelletti SM, Mercadante MCS, Padovani CR, Spadella CT. Role of metabolic control on diabetic nephropathy. Acta Cir Bras. 2002;17:37–5.CrossRef
  3.Sharma SB, Gupta S, Rani AC, Singh UR, Rajpoot R, Shukla SK. Antidiabetic action of Morus rubra L. leaf extract in streptozotocin- induced diabetic rats. J Pharm Pharmacol. 2010;62:247–55.PubMed
  4.Ediriweera ERHSS, Ratnasooriya WD. A review of herbs used in treatment of diabetes mellitus by Sri Lankan Ayurvedic and traditional physicians. Ayu. 2009;30:373–91.
  5.Jayaweera DMA. Medicinal Plants used in Ceylon. 1st ed. Sri Lanka: Gunasena MD & Co; 1982.
  6.Vasconcelos CF, Maranhão HM, Batista TM, Carneiro EM, Ferreira F, Costa J, et al. Hypoglycemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats. J Ethnopharmacol. 2011;137:1533–41.CrossRef PubMed
  7.Trinder P. Determination of blood glucose using an oxidase peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969;22:158–61.PubMedCentral CrossRef PubMed
  8.Purves RD. Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC). J Pharmacokin Biopharm. 1992;20:211–27.CrossRef
  9.Trease GE, Evans WC. Pharmacology. London: Bailliere Tindall Ltd; 1978. p. 60–75.
  10.Dhawan BN, Srimal RC. Acute toxicity and gross effects. In: “Laboratory manual for pharmacological evaluation of natural products”. United Nations Industrial Development Organization and International Center for Science and High Technology. 1980;17–20
  11.Etuk EU. Animal models for studying diabetes mellitus. Agric Biol J N Am. 2010;1:130–4.
  12.Frode TS, Medeiros YS. Animal models to test drugs with potential antidiabetic activity. J Ethnopharmacol. 2008;115:173–83.CrossRef PubMed
  13.Herrera C, García-Barrantes PM, Binns F, Vargas M, Poveda L, Badilla S. Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats. J Ethnopharmacol. 2011;133:907–10.CrossRef PubMed
  14.Ndong M, Uehara M, Katsumata S, Suzuki K. Effects of oral administration of Moringa oleifera Lam on glucose tolerance in Goto-Kakizaki and Wistar Rats. J Clin Biochem Nutr. 2007;40:229–33.PubMedCentral CrossRef PubMed
  15.Palacios-Espinosa F, Déciga-Campos M, Mata R. Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia. J Ethnopharmacol. 2008;118:448–54.CrossRef PubMed
  16.Victoria Ukwe C, Michael Ubaka C. Hypoglycemic activity of leaves of Acanthus montanus T. Anderson (Acanthaceae) in rats. Int J Diabetes Dev Ctries. 2011;31:32–6.CrossRef
  17.Adeghate E, Singh J, Cumming E, Manoharan G, Kalasz H. Medicinal chemistry of the anti-diabetic effects of Momordica charantia: active constituents and modes of actions. Open Med Chem J. 2011;5:70–7.PubMedCentral CrossRef PubMed
  18.Stephen-Irudayaraj S, Sunil C, Duraipandiyan V, Ignacimuthu S. Antidiabetic and antioxidant activities of Toddalia asiatica (L.) Lam. leaves in streptozotocin induced diabetic rats. J Ethnopharmacol. 2012;143:515–23.CrossRef PubMed
  19.Salahuddin M, Jalalpure SS. Comparative hypoglycemic effects of Cassia glauca Lam. in streptozotocin- induced diabetic rats. The Int J Pharmacol. 2010. doi:10.​5580/​25f9 .
  20.Ali L, Khan AK, Mamun MI, Mosihuzzaman M, Nahar N, Nur-e-Alam M, et al. Studies on hypoglycemic effects of fruit pulp, seed, and whole plant of Momordica charantia on normal and diabetic model rats. Planta Med. 1993;59:408–12.CrossRef PubMed
  21.Karunanayake EH, Jeevathayaparan S, Tennekoon KH. Effect of Momordica charantia fruit juice on streptozotocin-induced diabetes in rats. J Ethnopharmacol. 1990;30:199–5.CrossRef PubMed
  22.Verspohi EJ. Recommended testing in diabetes research. Planta Med. 2002;68:581–90.CrossRef
  23.Rawi SM, Mourad IM, Sayed DA. Biochemical changes in experimental diabetes before and after treatment with Mangifera indica and Psidum guava extracts. Int J Pharm Sci. 2011;2:29–41.
  
• 作者单位：Anoja Priyadarshani Attanayake (1)
  Kamani Ayoma Perera Wijewardena Jayatilaka (1)
  Chitra Pathirana (1)
  Lakmini Kumari Boralugoda Mudduwa (2)
  
  1. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Ruhuna, Sri Lanka
  2. Department of Pathology, Faculty of Medicine, University of Ruhuna, Ruhuna, Sri Lanka
  
• 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Health Administration; Diabetes;
• 出版者：Springer India
• ISSN：1998-3832

文摘

The efficacy and dose response of oral hypoglycemic and antihyperglycemic effects of ten Sri Lankan plant extracts on glucose tolerance were evaluated in healthy and streptozotocin induced diabetic rats. A single dose of 0.25, 0.50, 0.75, 1.00, 1.25 and 2.00 g/kg of plant extracts was administered orally to healthy and streptozotocin induced (65 mg/kg, ip) diabetic Wistar rats (N = 6). Glibenclamide (0.50 mg/kg) was used as the standard drug. The optimum effective dose of each extract and the percentage of improvement at the optimum effective dose were evaluated over a four hour period using area under the oral glucose tolerance curve. The percentage improvement on glucose tolerance at the optimum effective dose was in the decreasing order of Momordica charantia (9.00 %), Coccinia grandis (8.50 %), Spondias pinnata (8.14 %), Gmelina arborea (7.69 %), Scoparia dulcis (7.43 %) in healthy rats. All ten plant extracts showed dose dependent improvement on glucose tolerance in streptozotocin induced diabetic rats (P < 0.05). The optimum effective dose on glucose tolerance for eight extracts was found to be 1.00 g/kg in diabetic rats with the exception of Coccinia grandis : 0.75 g/kg and Momordica charantia : 0.50 g/kg. The plant extracts studied showed dose dependent improvement on glucose tolerance at and above the optimum effective dose in streptozotocin induced diabetic rats. The optimum effective dose was found to be approximately equal to the therapeutic dose of each extract.