Preparation of Monolithic Capillary Chromatographic Columns Using Supercritical Fluid as a Porogen Solvent

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• 作者：Micha? Szumski (1)
  Bogus?aw Buszewski (1)
  
• 关键词：Capillary liquid chromatography ; Monolithic polymeric column ; Porogen solvent ; Supercritical carbon dioxide
• 刊名：Chromatographia
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：77
• 期：15-16
• 页码：1009-1017
• 全文大小：884 KB
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• 作者单位：Micha? Szumski (1)
  Bogus?aw Buszewski (1)
  
  1. Faculty of Chemistry, Department of Environmental Chemistry and Bioanalytics, Nicolaus Copernicus University, Gagarina 7, 87-100, Toruń, Poland
  
• ISSN：1612-1112

文摘

Monolithic polymeric beds were synthesized in fused silica capillaries using either trimethylolpropane trimethacrylate (TRIM) or a mixture of butyl methacrylate (BMA) with ethylene glycol dimethacrylate (EDMA) as monomers. Carbon dioxide at temperature and pressure conditions above its critical values was used as a porogen solvent. The purpose of using the supercritical carbon dioxide was to have the possibility of changing the solvation power (and thus the porosity of the resulting monolith) of the porogen by pressure and temperature changes instead of changing the porogen composition. The experiments were performed using a special setup consisting of a stainless steel high-pressure reactor to which the fused silica capillary was connected. The synthesized monoliths underwent liquid chromatographic evaluation. The polyTRIM capillary monoliths were characterized by different permeability, which depended on the pressure of the synthesis. BMA/EDMA columns were applied for separation of alkylbenzenes and a model mixture of proteins.