In-vitro experimental analysis of magnetic fluid hyperthermia in soft tissue with artificial blood perfusion

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• 作者：Mohammad Mahdi Attar ; Farzan Barati…
• 关键词：Nanoparticles ; Magnetic fluid ; Electromagnetic biology ; Kidney ; Finite element methods ; Artificial blood perfusions
• 刊名：Journal of Mechanical Science and Technology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：465-472
• 全文大小：
• 刊物类别：Engineering
• 刊物主题：Mechanical Engineering; Vibration, Dynamical Systems, Control; Industrial and Production Engineering;
• 出版者：Korean Society of Steel Construction
• ISSN：1976-3824
• 卷排序：31

文摘

Magnetic fluid exposed to an alternating magnetic field generates heat that it can be used for treatment and removal of cancerous tissue. The aim of this study is to investigate the thermal behavior of kidney tissue in magnetic fluid hyperthermia. Considering the fact that doing experiments on live tissue have some limitations, a new method is provided to test on dead tissue. In this study, an artificial circulation of the current vessels of kidney is used to make closer the behavior of dead tissue to live ones. The superparamagnetic nanoparticles with an average diameter of 20 nm have been used to heat tissue and an overview of the hardware devices needed to generate a magnetic field and to record temperature has been mentioned. Finally, the heating process has been simulated by the finite element software of Ansys. The nanoparticles injected to the tissue have a relatively spherical distribution which inevitably increases with increasing the intensity of the magnetic field and temperature difference dose. On the other hand it was observed that the rate of blood flow plays a key role in the analysis of tissue behavior and it is able to decrease the rise in temperature at most 70 %. Based on the results, it is inferred that the circulation along magnetic field intensity and dose of nanoparticles, plays a key role in the process of heating the tissue.