Microglial activation in Parkinson’s disease using [¹⁸F]-FEPPA

详细信息    查看全文

• 作者：Christine Ghadery ; Yuko Koshimori ; Sarah Coakeley…
• 关键词：Neuroinflammation ; TSPO imaging ; PET ; Parkinson’s disease
• 刊名：Journal of Neuroinflammation
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：14
• 期：1
• 全文大小：683KB
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094
• 卷排序：14

文摘

BackgroundNeuroinflammatory processes including activated microglia have been reported to play an important role in Parkinson’s disease (PD). Increased expression of translocator protein (TSPO) has been observed after brain injury and inflammation in neurodegenerative diseases. Positron emission tomography (PET) radioligand targeting TSPO allows for the quantification of neuroinflammation in vivo.