Ezrin Expression as a Prognostic Marker in Colorectal Adenocarcinoma

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• 作者：Marcelo Patara (1)
  Erika Maria Monteiro Santos (2)
  Renata de Almeida Coudry (3)
  Fernando Augusto Soares (3)
  Fábio Oliveira Ferreira (4)
  Benedito Mauro Rossi (4)
  
• 关键词：Colorectal cancer ; Ezrin ; Biological marker ; Prognostic ; Adenocarcinoma
• 刊名：Pathology & Oncology Research
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：17
• 期：4
• 页码：827-833
• 全文大小：303KB
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• 作者单位：Marcelo Patara (1)
  Erika Maria Monteiro Santos (2)
  Renata de Almeida Coudry (3)
  Fernando Augusto Soares (3)
  Fábio Oliveira Ferreira (4)
  Benedito Mauro Rossi (4)
  
  1. CNPq—PIBIC, College of Medical Sciences Santa Casa de S?o Paulo, Rua Professor Antonio Prudente, 211, 01509-10, Sao Paulo, SP, Brazil
  2. Center of Research, Hospital A.C.Camargo, Sao Paulo, Brazil
  3. Department of Pathological Anatomy, Hospital A.C.Camargo, Sao Paulo, Brazil
  4. Department of Pelvic Surgery, Hospital A.C.Camargo, Sao Paulo, Brazil
  
• ISSN：1532-2807

文摘

Ezrin protein acts in the regulation of cytoskeletal and directly influences survival and tumor progression; there is an increase in its expression in metastatic cells and tissues in several types of cancer including colorectal cancer. 250 Patients with colorectal cancer submitted to surgery from 1995 to 2002. Protein expression was carried through by Tissue Micro Array immunohistochemical tests of paraffined neoplasic tissues and associated with clinical variables. Differentiation degree, lymph node invasion, metastasis at diagnosis, and palliative surgery were associated to a higher expression of the protein and survival. Higher expression of the Ezrin correlates with tumor aggressiveness and worse prognosis for colorectal cancer.