Quantification of two isomeric flavones in rat colon tissue using reverse phase high performance liquid chromatography

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• 作者：Crystal L. Whitted ; Victoria E. Palau ; Ruben D. Torrenegra…
• 关键词：5 ; 7 ; Dihydroxy ; 3 ; 6 ; 8 ; trimethoxy flavone ; 3 ; 5 ; Dihydroxy ; 6 ; 7 ; 8 ; trimethoxy flavone ; HPLC ; Colon ; Flavonoids ; Cancer
• 刊名：BMC Research Notes
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：10
• 期：1
• 全文大小：1428KB
• 刊物主题：Biomedicine, general; Medicine/Public Health, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1756-0500
• 卷排序：10

文摘

BackgroundAntineoplastic activity has been previously shown for two isomeric flavones, 5,7-dihydroxy-3,6,8-trimethoxy flavone (flavone A) and 3,5-dihydroxy-6,7,8-trimethoxy flavone (flavone B), against colon cancer cell lines (Thomas et al. in PLoS ONE 7:e39806, 5). Here, we present modified methods for the extraction and quantification of flavones A and B in rat colon tissue after intravenous dosing via high performance liquid chromatography, from the originally described procedure for extraction and quantification in rat plasma (Whitted et al. in J Chromatogr B Analyt Technol Biomed Life Sci 1001:150–155, 7).