MicroRNA-155 in serum-derived extracellular vesicles as a potential biomarker for hematologic malignancies - a short report

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• 作者：Antonella Caivano ; Francesco La Rocca ; Vittorio Simeon ; Marco GirasoleR30
• 关键词：miR155 ; Extracellular vesicles ; Chronic lymphocytic leukemia ; Waldenström’s macroglobulinemia ; Myelodysplastic syndrome ; Acute myeloid leukemia
• 刊名：Cellular Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：1
• 页码：97-103
• 全文大小：
• 刊物主题：Cancer Research; Biomedicine, general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436
• 卷排序：40

文摘

PurposeThe use of extracellular vesicles (EVs) from body fluids as “liquid biopsies” is emerging as a promising approach for the diagnosis, prognosis and therapeutic monitoring of cancer patients. MicroRNA-155 (miR155), a non-coding transcript of the B-cell integration cluster (BIC) gene, has been reported to play a critical role in the pathogenesis of several types of hematologic malignancies (HMs) in which high miR155 levels have been found. At yet, however, the EV miR155 level and its putative clinical relevance in sera of HM patients have not been reported.