The impact of APOL1, CAV1, and ABCB1 gene variants on outcomes in kidney transplantation: donor and recipient effects

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• 作者：Amudha Palanisamy (1)
  Amber M. Reeves-Daniel (1)
  Barry I. Freedman (1)
  
• 关键词：ABCB1 ; APOL1 ; CAV1 ; Genetics ; Kidney disease ; Transplantation
• 刊名：Pediatric Nephrology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：29
• 期：9
• 页码：1485-1492
• 全文大小：190 KB
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• 作者单位：Amudha Palanisamy (1)
  Amber M. Reeves-Daniel (1)
  Barry I. Freedman (1)
  
  1. Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1053, USA
  
• ISSN：1432-198X

文摘

Dramatic improvements have been seen in short-term kidney allograft survival over recent decades with introduction of more potent immunosuppressant medications and regimens. Unfortunately, improvements in long-term graft survival have lagged behind. The genomics revolution is providing new insights regarding the potential impact of kidney donor genotypes on long-term graft survival. Variation in the donor apolipoprotein L1 (APOL1), caveolin 1 (CAV1), and multi-drug resistance 1 encoding P-glycoprotein genes (ABCB1) are all associated with graft survival after kidney transplantation. Although the precise mechanisms whereby these donor gene variants confer risk for graft loss have yet to be determined, these findings provide novel opportunities for modifying interactive environmental factors and optimizing kidney allocation with the ultimate goal of improving long-term graft survival rates.