Sentinel lymph node biopsy in oral and oropharyngeal squamous cell carcinoma: current status and unresolved challenges

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• 作者：Christina Bluemel ; Domenico Rubello…
• 关键词：Sentinel lymph node ; Oral cancer ; Neck dissection ; Squamous cell carcinoma ; Intraoperative imaging ; Radioguided
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：42
• 期：9
• 页码：1469-1480
• 全文大小：663 KB
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• 作者单位：Christina Bluemel (1)
  Domenico Rubello (2)
  Patrick M. Colletti (3)
  Remco de Bree (4)
  Ken Herrmann (1)
  
  1. Department of Nuclear Medicine, University Hospital of W眉rzburg, Oberd眉rrbacher Str. 6, 97080, W眉rzburg, Germany
  2. Department of Nuclear Medicine-PET/CT Oncologic & Endocrine Sections, Rovigo Hospital, Rovigo, Italy
  3. Department of Radiology, University of Southern California, Los Angeles, CA, USA
  4. Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Center, Utrecht, The Netherlands
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nuclear Medicine
  Imaging and Radiology
  Orthopedics
  Cardiology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1619-7089

文摘

Because imaging with ultrasound, computed tomography, magnetic resonance imaging or positron emission tomography is unreliable for preoperative lymph node staging of early-stage oral and oropharyngeal squamous cell carcinoma (OSCC), elective neck dissection has been typically performed. The targeted sampling of sentinel lymph nodes (SLN) identified by lymphoscintigraphy and detected by gamma probe has become an effective alternative for the selection of patients for regional nodal resection. With careful consideration to technique, high SLN detection rates have been reported. Advanced techniques including intraoperative handheld gamma camera imaging and freehand single photon emission computed tomography (SPECT) are expected to increase surgical confidence in these procedures. This review gives an update on SLN biopsy in patients with OSCC including clinical standards and controversial aspects.