Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task

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• 作者：Fiona D. Zeeb ; P. J. J. Baarendse ; L. J. M. J. Vanderschuren…
• 关键词：Anterior cingulate cortex ; Decision ; making ; Dopamine receptor ; Infralimbic cortex ; Orbitofrontal cortex ; Prelimbic cortex ; Rat gambling task ; Reward ; Punishment ; Probability
• 刊名：Psychopharmacology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：232
• 期：24
• 页码：4481-4491
• 全文大小：1,441 KB
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• 作者单位：Fiona D. Zeeb (1) (4)
  P. J. J. Baarendse (2)
  L. J. M. J. Vanderschuren (2) (3)
  Catharine A. Winstanley (1)
  
  1. Department of Psychology, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
  4. Centre for Addiction and Mental Health, Section of Biopsychology, Campbell Family Mental Health Research Institute, Toronto, ON, Canada
  2. Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
  3. Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Pharmacology and Toxicology
  Psychiatry
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-2072

文摘

Rationale Studies employing the Iowa Gambling Task (IGT) demonstrated that areas of the frontal cortex, including the ventromedial prefrontal cortex, orbitofrontal cortex (OFC), dorsolateral prefrontal cortex, and anterior cingulate cortex (ACC), are involved in the decision-making process. However, the precise role of these regions in maintaining optimal choice is not clear.