刊名:Journal of Experimental & Clinical Cancer Research
出版年:2017
出版时间:December 2017
年:2017
卷:36
期:1
全文大小:4234KB
刊物主题:Oncology; Cancer Research; Immunology; Apoptosis;
出版者:BioMed Central
ISSN:1756-9966
卷排序:36
文摘
BackgroundRecent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). Forkhead box M1 (FoxM1) controls the expression of a number of cell cycle regulatory proteins, and FoxM1 expression is elevated in a broad range of human malignancies, which suggests that it plays a crucial role in tumorigenesis. However, the mechanisms underlying FoxM1 expression are not fully understood. Here, we aim to further investigate the molecular mechanism by which Gli1 regulates FoxM1 in CRC.
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.