Variable-Internal-Stores models of microbial growth and metabolism with dynamic allocation of cellular resources

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• 作者：Olga A. Nev ; Hugo A. van den Berg
• 关键词：Microbial growth ; Multiple nutrient limitation ; Cellular resource allocation ; Physiological regulation
• 刊名：Journal of Mathematical Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：74
• 期：1-2
• 页码：409-445
• 全文大小：1388KB
• 刊物类别：Mathematics and Statistics
• 刊物主题：Mathematical and Computational Biology; Applications of Mathematics;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1416
• 卷排序：74

文摘

Variable-Internal-Stores models of microbial metabolism and growth have proven to be invaluable in accounting for changes in cellular composition as microbial cells adapt to varying conditions of nutrient availability. Here, such a model is extended with explicit allocation of molecular building blocks among various types of catalytic machinery. Such an extension allows a reconstruction of the regulatory rules employed by the cell as it adapts its physiology to changing environmental conditions. Moreover, the extension proposed here creates a link between classic models of microbial growth and analyses based on detailed transcriptomics and proteomics data sets. We ascertain the compatibility between the extended Variable-Internal-Stores model and the classic models, demonstrate its behaviour by means of simulations, and provide a detailed treatment of the uniqueness and the stability of its equilibrium point as a function of the availabilities of the various nutrients.