Reducing the risk of impaired bone apposition to titanium screws with the use of fibroblast growth factor-2−apatite composite layer coating

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• 作者：Kengo Fujii ; Atsuo Ito ; Hirotaka Mutsuzaki…
• 关键词：Fibroblast growth factor ; 2 (FGF ; 2) ; Apatite ; Coating ; Titanium screw ; Bone formation ; Weibull plot analysis ; Impaired bone formation risk
• 刊名：Journal of Orthopaedic Surgery and Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：1
• 全文大小：954KB
• 刊物主题：Orthopedics; Surgical Orthopedics;
• 出版者：BioMed Central
• ISSN：1749-799X
• 卷排序：12

文摘

BackgroundLoosening of screws is a common problem in orthopedic and maxillofacial surgery. Modifying the implant surface to improve the mechanical strength of screws has been tried and reported. We developed screws coated with fibroblast growth factor-2 (FGF-2)−apatite composite layers. We then showed, in a percutaneous external fixation model, that this composite layer had the ability to hold and release FGF-2 slowly, thereby reducing the risk of pin tract infection of the percutaneous external fixation. The objective of the current study was to clarify the effect of FGF-2−apatite composite layers on titanium screws on bone formation around the screw.