Integrated anti-remodeling and anabolic therapy for the osteoporosis of Hajdu–Cheney syndrome

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• 作者：F. E. McKiernan
• 关键词：Bone mineral density ; Hajdu–Cheney syndrome ; Osteoporosis ; Remodeling
• 刊名：Osteoporosis International
• 出版年：2007
• 出版时间：February, 2007
• 年：2007
• 卷：18
• 期：2
• 页码：245-249
• 全文大小：234 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  Gynecology
  Endocrinology
  Rheumatology
  
• 出版者：Springer London
• ISSN：1433-2965

文摘

Hajdu–Cheney syndrome (MIM 102500) is a rare skeletal dysplasia marked by severe generalized osteoporosis and focal bone loss (acro-osteolysis). Osteoporosis treatment outcome has been reported only once previously. Reported herein is the biochemical and densitometric response to integrated anti-remodeling and anabolic therapy in a woman with Hajdu–Cheney syndrome. Results suggest dissociation of bone formation from bone resorption resulting in dramatic increases in bone mineral density without clinical evidence of activated osteoporosis.