The biological effects of hsa-miR-1908 in human adipocytes

详细信息    查看全文

• 作者：Lei Yang (1) (2)
  Chun-mei Shi (1) (2)
  Ling Chen (1) (2)
  Ling-xia Pang (1) (2)
  Guang-feng Xu (3)
  Nan Gu (2)
  Li-jun Zhu (2)
  Xi-rong Guo (1) (2)
  Yu-hui Ni (1) (2)
  Chen-bo Ji (1) (2)
  
  1. Institute of Pediatrics ; Nanjing Medical University ; No. 140 Hanzhong Road ; Nanjing ; 210029 ; China
  2. Department of Children Health Care ; Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University ; No. 123 Tianfei Road ; Nanjing ; 210004 ; China
  3. Department of Laboratory Medicine ; The 82nd Hospital of the People鈥檚 Liberation Army ; No. 100 Jiankang East Road ; Huaian ; 223001 ; China
  
• 关键词：Obesity ; Hsa ; miR ; 1908 ; Human adipocytes ; Adipogenisis
• 刊名：Molecular Biology Reports
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：42
• 期：5
• 页码：927-935
• 全文大小：1,029 KB
• 参考文献：1. D鈥橝iuto, F, Suvan, J (2012) Obesity, inflammation, and oral infections: are microRNAs the missing link?. J Dent Res 91: pp. 5-7 CrossRef
  2. Rodriguez, AM, Elabd, C, Delteil, F, Astier, J, Vernochet, C, Saint-Marc, P (2004) Adipocyte differentiation of multipotent cells established from human adipose tissue. Biochem Biophys Res Commun 315: pp. 255-263 CrossRef
  3. Zuk, PA, Zhu, M, Ashjian, P, Ugarte, DA, Huang, JI, Mizuno, H (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13: pp. 4279-4295 CrossRef
  4. Spalding, KL, Arner, E, Westermark, PO, Bernard, S, Buchholz, BA, Bergmann, O (2008) Dynamics of fat cell turnover in humans. Nature 453: pp. 783-787 CrossRef
  5. Ambros, V (2004) The functions of animal microRNAs. Nature 431: pp. 350-355 CrossRef
  6. Bartel, DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: pp. 281-297 CrossRef
  7. Zamore, PD, Haley, B (2005) Ribo-gnome: the big world of small RNAs. Science 309: pp. 1519-1524 CrossRef
  8. Baltimore, D, Boldin, MP, O鈥機onnell, RM, Rao, DS, Taganov, KD (2008) MicroRNAs: new regulators of immune cell development and function. Nat Immunol 9: pp. 839-845 CrossRef
  9. Stefani, G, Slack, FJ (2008) Small non-coding RNAs in animal development. Nat Rev Mol Cell Biol 9: pp. 219-230 CrossRef
  10. Sacco, J, Adeli, K (2012) MicroRNAs: emerging roles in lipid and lipoprotein metabolism. Curr Opin Lipidol 23: pp. 220-225 CrossRef
  11. Lee, RC, Feinbaum, RL, Ambros, V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: pp. 843-854 CrossRef
  12. Griffiths-Jones, S (2004) The microRNA Registry. Nucleic Acids Res 32: pp. D109-11
  13. Xie, H, Lim, B, Lodish, HF (2009) MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58: pp. 1050-1057 CrossRef
  14. Esau, C, Kang, X, Peralta, E, Hanson, E, Marcusson, EG, Ravichandran, LV (2004) MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 279: pp. 52361-52365 CrossRef
  15. Wang, Q, Li, YC, Wang, J, Kong, J, Qi, Y, Quigg, RJ (2008) miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci USA 105: pp. 2889-2894 CrossRef
  16. Kim, YJ, Hwang, SJ, Bae, YC, Jung, JS (2009) MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 27: pp. 3093-3102
  17. Karbiener, M, Neuhold, C, Opriessnig, P, Prokesch, A, Bogner-Strauss, JG, Scheideler, M (2011) MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2. RNA Biol 8: pp. 850-860 CrossRef
  18. Huang, J, Zhao, L, Xing, L, Chen, D (2010) MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells 28: pp. 357-364
  19. Lee, EK, Lee, MJ, Abdelmohsen, K, Kim, W, Kim, MM, Srikantan, S (2011) miR-130 suppresses adipogenesis by inhibiting peroxisome proliferator-activated receptor gamma expression. Mol Cell Biol 31: pp. 626-638 CrossRef
  20. Lin, Q, Gao, Z, Alarcon, RM, Ye, J, Yun, Z (2009) A role of miR-27 in the regulation of adipogenesis. FEBS J 276: pp. 2348-2358 CrossRef
  21. Bar, M, Wyman, SK, Fritz, BR, Qi, J, Garg, KS, Parkin, RK (2008) MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells 26: pp. 2496-2505 CrossRef
  22. Pencheva, N, Tran, H, Buss, C, Huh, D, Drobnjak, M, Busam, K (2012) Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell 151: pp. 1068-1082 CrossRef
  23. Wang, WJ, Wang, KA, Li, TL, Xiang, HD, Ma, LM, Fu, ZY (2002) A discussion on utility and purposed value of obesity and abdomen obesity when body mass index, waist circumference, waist to hip ratio used as indexes predicting hypertension and hyper-blood glucose. Zhonghua Liu Xing Bing Xue Za Zhi 23: pp. 16-19
  24. Heidi, JP, Gary, JL (2008) Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues. RNA 14: pp. 844-852 CrossRef
  25. Neville, MJ, Collins, JM, Gloyn, AL, McCarthy, MI, Karpe, F (2011) Comprehensive human adipose tissue mRNA and microRNA endogenous聽control聽selection for quantitative real-time-PCR normalization. Obesity 19: pp. 888-892 CrossRef
  26. Sun, T, Fu, M, Bookout, AL, Kliewer, SA, Mangelsdorf, DJ (2009) MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol 23: pp. 925-931 CrossRef
  27. Vannucci, L, Lai, M, Chiuppesi, F, Ceccherini-Nelli, L, Pistello, M (2013) Viral vectors: a look back and ahead on gene transfer technology. New Microbiol 36: pp. 1-22
  28. Haslam, DW, James, WP (2005) Obesity. Lancet. 366: pp. 1197-1209 140-6736(05)67483-1" target="_blank" title="It opens in new window">CrossRef
  29. Song, GX, Xu, GF, Ji, CB, Shi, CM, Shen, YH, Chen, L (2014) The role of microRNA-26b in human adipocyte differentiation and proliferation. Gene 533: pp. 481-487 CrossRef
  30. Chen, L, Dai, YM, Ji, CB, Yang, L, Shi, CM, Xu, GF (2014) MiR-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression isaltered in human obesity. Mol Cell Endocrinol 5: pp. 393(1鈥?)
  31. Gao, D, Bing, C (2011) Macrophage-induced expression and release of matrix metalloproteinase 1 and 3 by human preadipocytes is mediated by IL-1beta via activation of MAPK signaling. J Cell Physiol 226: pp. 2869-2880 CrossRef
  32. Wu, WL, Gan, WH, Tong, ML, Li, XL, Dai, JZ, Zhang, CM (2011) Over-expression of NYGGF4 (PID1) inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3聽K/AKT insulin pathway. Mol Genet Metab 102: pp. 374-377 CrossRef
  33. Long, C, Jiang, L, Wei, F, Ma, C, Zhou, H, Yang, S (2013) Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas. PLoS ONE 8: pp. e66676 CrossRef
  34. Jin, JC, Jin, XL, Zhang, X, Piao, YS, Liu, SP (2013) Effect of OSW-1 on microRNA expression profiles of hepatoma cells and functions of novel microRNAs. Mol Med Rep. 7: pp. 1831-1837
  35. Kajimoto, K, Naraba, H, Iwai, N (2006) MicroRNA and 3T3-L1 pre-adipocyte differentiation. RNA 12: pp. 1626-1632 CrossRef
  36. Otto, TC, Lane, MD (2005) Adipose development: from stem cell to adipocyte. Crit Rev Biochem Mol Biol 40: pp. 229-242 CrossRef
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Animal Anatomy, Morphology and Histology
  Animal Biochemistry
  
• 出版者：Springer Netherlands
• ISSN：1573-4978

文摘

MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. MiR-1908 is a recently identified miRNA that is highly expressed in human adipocytes. However, it is not known what role of miR-1908 is involved in the regulation of human adipocytes. In this study, we demonstrate that the level of miR-1908 increases during the adipogenesis of human multipotent adipose-derived stem (hMADS) cells and human preadipocytes-visceral. Overexpression of miR-1908 in hMADS cells inhibited adipogenic differentiation and increased cell proliferation, suggesting that miR-1908 is involved in the regulation of adipocyte cell differentiation and metabolism, and, thus, may have an effect on human obesity.