Specific eradication of HIV-1 from infected cultured cells

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• 作者：Aviad Levin (1)
  Zvi Hayouka (2)
  Assaf Friedler (2)
  Abraham Loyter (1)
  
• 刊名：AIDS Research and Therapy
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：7
• 期：1
• 全文大小：998KB
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• 作者单位：Aviad Levin (1)
  Zvi Hayouka (2)
  Assaf Friedler (2)
  Abraham Loyter (1)
  
  1. Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences; The Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem, 91904, Israel
  2. Institute of Chemistry; The Hebrew University of Jerusalem ,Safra Campus, Givat Ram, Jerusalem, 91904, Israel
  
• ISSN：1742-6405

文摘

A correlation between increase in the integration of Human Immunodeficiency virus-1 (HIV-1) cDNA and cell death was previously established. Here we show that combination of peptides that stimulate integration together with the protease inhibitor Ro 31-8959 caused apoptotic cell death of HIV infected cells with total extermination of the virus. This combination did not have any effect on non-infected cells. Thus it appears that cell death is promoted only in the infected cells. It is our view that the results described in this work suggest a novel approach to specifically promote death of HIV-1 infected cells and thus may eventually be developed into a new and general anti-viral therapy.