Radiotherapy for tumors of the stomach and gastroesophageal junction -a review of its role in multimodal therapy

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• 作者：Daniel Buergy (1)
  Frank Lohr (1)
  Tobias Baack (1)
  Kerstin Siebenlist (1)
  Stefan Haneder (2)
  Henrik Michaely (2)
  Frederik Wenz (1)
  Judit Boda-Heggemann (1)
  
• 关键词：Stomach ; Gastric cancer ; Gastroesophageal junction ; Radiotherapy ; Adjuvant therapy ; Neoadjuvant ; Radiochemotherapy
• 刊名：Radiation Oncology
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：7
• 期：1
• 全文大小：532KB
• 参考文献：1. Bertuccio P, Chatenoud L, Levi F, Praud D, Ferlay J, Negri E, Malvezzi M, La Vecchia C: Recent patterns in gastric cancer: a global overview. / Int J Cancer 2009, 125:666-73. CrossRef
  2. Siegel R, Ward E, Brawley O, Jemal A: Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. / CA Cancer J Clin 2011, 61:212-36. CrossRef
  3. Boyle P, Ferlay J: Cancer incidence and mortality in Europe, 2004. / Ann Oncol 2005, 16:481-88. CrossRef
  4. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. / CA Cancer J Clin 2011, 61:69-0. CrossRef
  5. Botterweck AA, Schouten LJ, Volovics A, Dorant E, van Den Brandt PA: Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries. / Int J Epidemiol 2000, 29:645-54. CrossRef
  6. Powell J, McConkey CC: The rising trend in oesophageal adenocarcinoma and gastric cardia. / Eur J Cancer Prev 1992, 1:265-69. CrossRef
  7. Blot WJ, Devesa SS, Kneller RW, Fraumeni JF Jr: Rising incidence of adenocarcinoma of the esophagus and gastric cardia. / JAMA 1991, 265:1287-289. CrossRef
  8. Okabayashi T, Gotoda T, Kondo H, Inui T, Ono H, Saito D, Yoshida S, Sasako M, Shimoda T: Early carcinoma of the gastric cardia in Japan: is it different from that in the West? / Cancer 2000, 89:2555-559. CrossRef
  9. Chung JW, Lee GH, Choi KS, Kim DH, Jung KW, Song HJ, Choi KD, Jung HY, Kim JH, Yook JH, / et al.: Unchanging trend of esophagogastric junction adenocarcinoma in Korea: experience at a single institution based on Siewert's classification. / Diseases of the esophagus: official journal of the International Society for Diseases of the Esophagus /ISDE 2009, 22:676-81. CrossRef
  10. Lagergren J, Bergstrom R, Nyren O: Association between body mass and adenocarcinoma of the esophagus and gastric cardia. / Ann Intern Med 1999, 130:883-90.
  11. Inoue M, Tajima K, Hirose K, Kuroishi T, Gao CM, Kitoh T: Life-style and subsite of gastric cancer–joint effect of smoking and drinking habits. / Int J Cancer 1994, 56:494-99. CrossRef
  12. Stein HJ, Feith M, Siewert JR: Cancer of the esophagogastric junction. / Surg Oncol 2000, 9:35-1. CrossRef
  13. Siewert JR, Holscher AH, Becker K, Gossner W: [Cardia cancer: attempt at a therapeutically relevant classification]. / Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 1987, 58:25-2.
  14. Wijnhoven BP, Siersema PD, Hop WC, van Dekken H, Tilanus HW: Adenocarcinomas of the distal oesophagus and gastric cardia are one clinical entity. Rotterdam Oesophageal Tumour Study Group. / Br J Surg 1999, 86:529-35. CrossRef
  15. Kodera Y, Yamamura Y, Shimizu Y, Torii A, Hirai T, Yasui K, Morimoto T, Kato T: Adenocarcinoma of the gastroesophageal junction in Japan: relevance of Siewert's classification applied to 177 cases resected at a single institution. / J Am Coll Surg 1999, 189:594-01. CrossRef
  16. Suh YS, Han DS, Kong SH, Lee HJ, Kim YT, Kim WH, Lee KU, Yang HK: Should adenocarcinoma of the esophagogastric junction be classified as esophageal cancer? A comparative analysis according to the seventh AJCC TNM classification. / Ann Surg 2012, 255:908-15. CrossRef
  17. Rice TW, Blackstone EH, Rusch VW: 7th edition of the AJCC Cancer Staging Manual: esophagus and esophagogastric junction. / Ann Surg Oncol 2010, 17:1721-724. CrossRef
  18. Edge SB (Ed): / AJCC cancer staging manual. 7 edition edition. New York, NY [u.a.]: Springer; 2010.
  19. Hartgrink HH, van de Velde CJ, Putter H, Bonenkamp JJ, Klein Kranenbarg E, Songun I, Welvaart K, van Krieken JH, Meijer S, Plukker JT, / et al.: Extended lymph node dissection for gastric cancer: who may benefit? Final results of the randomized Dutch gastric cancer group trial. / J Clin Oncol 2004, 22:2069-077. CrossRef
  20. Songun I, Putter H, Kranenbarg EM, Sasako M, van de Velde CJ: Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. / Lancet Oncol 2010, 11:439-49. CrossRef
  21. Cuschieri A, Weeden S, Fielding J, Bancewicz J, Craven J, Joypaul V, Sydes M, Fayers P: Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial. / Surgical Co-operative Group. Br J Cancer 1999, 79:1522-530. CrossRef
  22. Degiuli M, Sasako M, Ponti A: Morbidity and mortality in the Italian Gastric Cancer Study Group randomized clinical trial of D1 versus D2 resection for gastric cancer. / Br J Surg 2010, 97:643-49. CrossRef
  23. Tamura S, Takeno A, Miki H: Lymph node dissection in curative gastrectomy for advanced gastric cancer. / Int J Surg Oncol 2011, 2011:748745.
  24. Van Cutsem E, Van de Velde C, Roth A, Lordick F, Kohne CH, Cascinu S, Aapro M: Expert opinion on management of gastric and gastro-oesophageal junction adenocarcinoma on behalf of the European Organisation for Research and Treatment of Cancer (EORTC)-gastrointestinal cancer group. / Eur J Cancer 2008, 44:182-94. CrossRef
  25. Mariette C, Piessen G: Oesophageal cancer: how radical should surgery be? / Eur J Surg Oncol 2012, 38:210-13. CrossRef
  26. D'Angelica M, Gonen M, Brennan MF, Turnbull AD, Bains M, Karpeh MS: Patterns of initial recurrence in completely resected gastric adenocarcinoma. / Ann Surg 2004, 240:808-16. CrossRef
  27. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, Haller DG, Ajani JA, Gunderson LL, Jessup JM, Martenson JA: Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. / N Engl J Med 2001, 345:725-30. CrossRef
  28. Kim S, Lim DH, Lee J, Kang WK, MacDonald JS, Park CH, Park SH, Lee SH, Kim K, Park JO, / et al.: An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. / Int J Radiat Oncol Biol Phys 2005, 63:1279-285. CrossRef
  29. Smalley SR, Benedetti JK, Haller DG, Hundahl SA, Estes NC, Ajani JA, Gunderson LL, Goldman B, Martenson JA, Jessup JM, / et al.: Updated Analysis of SWOG-Directed Intergroup Study 0116: A Phase III Trial of Adjuvant Radiochemotherapy Versus Observation After Curative Gastric Cancer Resection. / J Clin Oncol 2012, 30:2327-333. CrossRef
  30. Brooks GA, Enzinger PC, Fuchs CS: Adjuvant therapy for gastric cancer: revisiting the past to clarify the future. / J Clin Oncol 2012, 30:2297-299. CrossRef
  31. Bajetta E, Buzzoni R, Mariani L, Beretta E, Bozzetti F, Bordogna G, Aitini E, Fava S, Schieppati G, Pinotti G, / et al.: Adjuvant chemotherapy in gastric cancer: 5-year results of a randomised study by the Italian Trials in Medical Oncology (ITMO) Group. / Ann Oncol 2002, 13:299-07. CrossRef
  32. Bouche O, Ychou M, Burtin P, Bedenne L, Ducreux M, Lebreton G, Baulieux J, Nordlinger B, Martin C, Seitz JF, / et al.: Adjuvant chemotherapy with 5-fluorouracil and cisplatin compared with surgery alone for gastric cancer: 7-year results of the FFCD randomized phase III trial (8801). / Ann Oncol 2005, 16:1488-497. CrossRef
  33. Nitti D, Wils J, Dos Santos JG, Fountzilas G, Conte PF, Sava C, Tres A, Coombes RC, Crivellari D, Marchet A, / et al.: Randomized phase III trials of adjuvant FAMTX or FEMTX compared with surgery alone in resected gastric cancer. A combined analysis of the EORTC GI Group and the ICCG. / Ann Oncol 2006, 17:262-69. CrossRef
  34. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, / et al.: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. / N Engl J Med 2006, 355:11-0. CrossRef
  35. Bickenbach K, Strong VE: Comparisons of Gastric Cancer Treatments: East vs. / West. Journal of gastric cancer 2012, 12:55-2. CrossRef
  36. D'Ugo D, Rausei S, Biondi A, Persiani R: Preoperative treatment and surgery in gastric cancer: friends or foes? / Lancet Oncol 2009, 10:191-95. CrossRef
  37. Lordick F, Siewert JR: Perioperative chemotherapy vs. surgery alone in resectable gastroesophageal carcinomas. Results of the MAGIC study. / Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2006, 77:1166-167. CrossRef
  38. Meyer HJ, Holscher AH, Lordick F, Messmann H, Monig S, Schumacher C, Stahl M, Wilke H, Mohler M: Current S3 guidelines on surgical treatment of gastric carcinoma. / Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 2012, 83:31-7. CrossRef
  39. Mihaljevic AL, Friess H, Schuhmacher C: Clinical trials in gastric cancer and the future. / J Surg Oncol 2012. http://www.ncbi.nlm.nih.gov/pubmed/22514058
  40. Dikken JL, van Sandick JW, Maurits Swellengrebel HA, Lind PA, Putter H, Jansen EP, Boot H, van Grieken NC, van de Velde CJ, Verheij M, Cats A: Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS). / BMC Cancer 2011, 11:329. CrossRef
  41. Klautke G, Fietkau R: Significance of radiation therapy for adenocarcinomas of the esophagus, gastroesophageal junction and gastric cancer with special reference to the MAGIC trial. / Strahlenther Onkol 2007, 183:163-69. CrossRef
  42. Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, Furukawa H, Nakajima T, Ohashi Y, Imamura H, / et al.: Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. / N Engl J Med 2007, 357:1810-820. CrossRef
  43. Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T, Nashimoto A, Fujii M, Nakajima T, Ohashi Y: Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. / J Clin Oncol 2011, 29:4387-393. CrossRef
  44. Nakajima T, Kinoshita T, Nashimoto A, Sairenji M, Yamaguchi T, Sakamoto J, Fujiya T, Inada T, Sasako M, Ohashi Y: Randomized controlled trial of adjuvant uracil-tegafur versus surgery alone for serosa-negative, locally advanced gastric cancer. / Br J Surg 2007, 94:1468-476. CrossRef
  45. Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY, / et al.: Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. / Lancet 2012, 379:315-21. CrossRef
  46. Ku GY, Ilson DH: Adjuvant therapy in esophagogastric adenocarcinoma: controversies and consensus, Gastrointestinal cancer research. / GCR 2012, 5:85-2.
  47. Mariette C, Piessen G, Triboulet JP: Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities. / Lancet Oncol 2007, 8:545-53. CrossRef
  48. Ando N, Iizuka T, Ide H, Ishida K, Shinoda M, Nishimaki T, Takiyama W, Watanabe H, Isono K, Aoyama N, / et al.: Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study–JCOG9204. / J Clin Oncol 2003, 21:4592-596. CrossRef
  49. Arnott SJ, Duncan W, Gignoux M, Hansen HS, Launois B, Nygaard K, Parmar MK, Rousell A, Spilopoulos G, Stewart G, / et al.: Preoperative radiotherapy for esophageal carcinoma. / Cochrane Database Syst Rev 2005, CD001799. http://www.ncbi.nlm.nih.gov/pubmed/16235286
  50. Zieren HU, Muller JM, Jacobi CA, Pichlmaier H, Muller RP, Staar S: Adjuvant postoperative radiation therapy after curative resection of squamous cell carcinoma of the thoracic esophagus: a prospective randomized study. / World J Surg 1995, 19:444-49. CrossRef
  51. Sjoquist KM, Burmeister BH, Smithers BM, Zalcberg JR, Simes RJ, Barbour A, Gebski V: Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis. / Lancet Oncol 2011, 12:681-92. CrossRef
  52. Allum WH, Stenning SP, Bancewicz J, Clark PI, Langley RE: Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. / J Clin Oncol 2009, 27:5062-067. CrossRef
  53. Kelsen DP, Winter KA, Gunderson LL, Mortimer J, Estes NC, Haller DG, Ajani JA, Kocha W, Minsky BD, Roth JA, Willett CG: Long-term results of RTOG trial 8911 (USA Intergroup 113): a random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer. / J Clin Oncol 2007, 25:3719-725. CrossRef
  54. Fiorica F, Di Bona D, Schepis F, Licata A, Shahied L, Venturi A, Falchi AM, Craxi A, Camma C: Preoperative chemoradiotherapy for oesophageal cancer: a systematic review and meta-analysis. / Gut 2004, 53:925-30. CrossRef
  55. Urschel JD, Vasan H: A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer. / Am J Surg 2003, 185:538-43. CrossRef
  56. Walsh TN, Noonan N, Hollywood D, Kelly A, Keeling N, Hennessy TP: A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. / N Engl J Med 1996, 335:462-67. CrossRef
  57. Stahl M, Walz MK, Stuschke M, Lehmann N, Meyer HJ, Riera-Knorrenschild J, Langer P, Engenhart-Cabillic R, Bitzer M, Konigsrainer A, / et al.: Phase III comparison of preoperative chemotherapy compared with chemoradiotherapy in patients with locally advanced adenocarcinoma of the esophagogastric junction. / J Clin Oncol 2009, 27:851-56. CrossRef
  58. Ychou M, Boige V, Pignon JP, Conroy T, Bouche O, Lebreton G, Ducourtieux M, Bedenne L, Fabre JM, Saint-Aubert B, / et al.: Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. / J Clin Oncol 2011, 29:1715-721. CrossRef
  59. van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, / et al.: Preoperative chemoradiotherapy for esophageal or junctional cancer. / N Engl J Med 2012, 366:2074-084. CrossRef
  60. Lee J, Lim Do H, / et al.: Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial. / J Clin Oncol 2012, 30:268-73. CrossRef
  61. Zhu WG, Xua DF, Pu J, Zong CD, Li T, Tao GZ, Ji FZ, Zhou XL, Han JH, Wang CS, / et al.: A randomized, controlled, multicenter study comparing intensity-modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection. / Radiother Oncol 2012. http://www.ncbi.nlm.nih.gov/pubmed?term=zhu%20xua%20a%20randomized%2C%20controlled%2C
  62. Yu C, Yu R, Zhu W, Song Y, Li T: Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery. / J Cancer Res Clin Oncol 2012, 138:255-59. CrossRef
  63. Dikken JL, Jansen EP, Cats A, Bakker B, Hartgrink HH, Kranenbarg EM, Boot H, Putter H, Peeters KC, van de Velde CJ, Verheij M: Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer. / J Clin Oncol 2010, 28:2430-436. CrossRef
  64. Smalley SR, Gunderson L, Tepper J, Martenson JA Jr, Minsky B, Willett C, Rich T: Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation. / Int J Radiat Oncol Biol Phys 2002, 52:283-93. CrossRef
  65. Gunderson LL, Sosin H: Adenocarcinoma of the stomach: areas of failure in a re-operation series (second or symptomatic look) clinicopathologic correlation and implications for adjuvant therapy. / Int J Radiat Oncol Biol Phys 1982, 8:1-1. CrossRef
  66. Caudry M, Ratoanina JL, Escarmant P, Maire JP: [Target volume in radiotherapy of gastric adenocarcinoma]. / Cancer Radiother 2001, 5:523-33. CrossRef
  67. Saikawa Y, Kubota T, Kumagai K, Nakamura R, Kumai K, Shigematsu N, Kubo A, Kitajima M, Kitagawa Y: Phase II study of chemoradiotherapy with S-1 and low-dose cisplatin for inoperable advanced gastric cancer. / Int J Radiat Oncol Biol Phys 2008, 71:173-79. CrossRef
  68. Jansen EP, Saunders MP, Boot H, Oppedijk V, Dubbelman R, Porritt B, Cats A, Stroom J, Valdes Olmos R, Bartelink H, Verheij M: Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer. / Int J Radiat Oncol Biol Phys 2007, 67:781-85. CrossRef
  69. Welz S, Hehr T, Kollmannsberger C, Bokemeyer C, Belka C, Budach W: Renal toxicity of adjuvant chemoradiotherapy with cisplatin in gastric cancer. / Int J Radiat Oncol Biol Phys 2007, 69:1429-435. CrossRef
  70. Oblak I, Velenik V, Anderluh F, Strojan P: Results of adjuvant radiochemotherapy for gastric adenocarcinoma in Slovenia. / Eur J Surg Oncol 2007, 33:982-87. CrossRef
  71. Bese NS, Buyukunal E, Ozguroglu M, Demir G, Yildirim A, Mandel NM, Demirelli F, Serdengecti S, Ober A: Toxicity and survival results of a phase II study investigating the role of postoperative chemo-radioimmunotherapy for gastric adenocarcinoma. / Strahlenther Onkol 2005, 181:652-59. CrossRef
  72. Corletto D, Iori M, Paiusco M, Brait L, Broggi S, Ceresoli G, Iotti C, Calandrino R, Fiorino C: Inverse and forward optimization of one- and two-dimensional intensity-modulated radiation therapy-based treatment of concave-shaped planning target volumes: the case of prostate cancer. / Radiother Oncol 2003, 66:185-95. CrossRef
  73. Wieland P, Dobler B, Mai S, Hermann B, Tiefenbacher U, Steil V, Wenz F, Lohr F: IMRT for postoperative treatment of gastric cancer: covering large target volumes in the upper abdomen: a comparison of a step-and-shoot and an arc therapy approach. / Int J Radiat Oncol Biol Phys 2004, 59:1236-244. CrossRef
  74. Lohr F, Dobler B, Mai S, Hermann B, Tiefenbacher U, Wieland P, Steil V, Wenz F: Optimization of dose distributions for adjuvant locoregional radiotherapy of gastric cancer by IMRT. / Strahlenther Onkol 2003, 179:557-63. CrossRef
  75. Dahele M, Skinner M, Schultz B, Cardoso M, Bell C, Ung YC: Adjuvant radiotherapy for gastric cancer: A dosimetric comparison of 3-dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans. / Medical dosimetry: official journal of the American Association of Medical Dosimetrists 2010, 35:115-21.
  76. Boda-Heggemann J, Haneder S, Konstandin S, Schad L, Wenz F, Michaely H, Lohr F: Assessment of 3D-conformal Radiotherapy (3DCRT) and Image-guided Intensity Modulated Radiotherapy (IG-IMRT) Induced Renal Damage by Means of Functional MR-imaging and 23Na-MR-imaging. / Int J Radiat Oncol Biol Phys 2011, 81:S326-S327. CrossRef
  77. Haneder S, Michaely HJ, Schoenberg SO, Konstandin S, Schad LR, Siebenlist K, Wertz H, Wenz F, Lohr F, Boda-Heggemann J: Assessment of renal function after conformal radiotherapy and intensity modulated radiotherapy by functional 1H-MR-imaging and 23Na-MR-imaging. / Strahlenther Onkol in press
  78. Kole TP, Aghayere O, Kwah J, Yorke ED, Goodman KA: Comparison of heart and coronary artery doses associated with intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for distal esophageal cancer. / Int J Radiat Oncol Biol Phys 2012, 83:1580-586. CrossRef
  79. Chakravarty T, Crane CH, Ajani JA, Mansfield PF, Briere TM, Beddar AS, Mok H, Reed VK, Krishnan S, Delclos ME, Das P: Intensity-modulated radiation therapy with concurrent chemotherapy as preoperative treatment for localized gastric adenocarcinoma. / Int J Radiat Oncol Biol Phys 2012, 83:581-86.
  80. Wolff D, Stieler F, Hermann B, Heim K, Clausen S, Fleckenstein J, Polednik M, Steil V, Wenz F, Lohr F: Clinical implementation of volumetric intensity-modulated arc therapy (VMAT) with ERGO++. / Strahlenther Onkol 2010, 186:280-88. CrossRef
  81. Rochet N, Sterzing F, Jensen A, Dinkel J, Herfarth K, Schubert K, Eichbaum M, Schneeweiss A, Sohn C, Debus J, Harms W: Helical tomotherapy as a new treatment technique for whole abdominal irradiation. / Strahlenther Onkol 2008, 184:145-49. CrossRef
  82. Martin S, Chen JZ, Rashid Dar A, Yartsev S: Dosimetric comparison of helical tomotherapy, RapidArc, and a novel IMRT & Arc technique for esophageal carcinoma. / Radiother Oncol 2011, 101:431-37. CrossRef
  83. Fan T, Jiang G, Suo Z, Liu H, Xu P, Ji Z, Zhang L, Yang G: Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells. / Int J Oncol 2009, 35:359-67.
  84. Nicolini G, Ghosh-Laskar S, Shrivastava SK, Banerjee S, Chaudhary S, Agarwal JP, Munshi A, Clivio A, Fogliata A, Mancosu P, / et al.: Volumetric Modulation Arc Radiotherapy With Flattening Filter-Free Beams Compared With Static Gantry IMRT and 3D Conformal Radiotherapy for Advanced Esophageal Cancer: A Feasibility Study. / Int J Radiat Oncol Biol Phys 2012, 84:553-60. CrossRef
  85. Vivekanandan N, Sriram P, Kumar SA, Bhuvaneswari N, Saranya K: Volumetric modulated arc radiotherapy for esophageal cancer. / Medical dosimetry: official journal of the American Association of Medical Dosimetrists 2012, 37:108-13.
  86. Van Benthuysen L, Hales L, Podgorsak MB: Volumetric modulated arc therapy vs. / IMRT for the treatment of distal esophageal cancer. Medical dosimetry: official journal of the American Association of Medical Dosimetrists 2011, 36:404-09.
  87. Hu W, Ye J, Wang J, Xu Q, Zhang Z: Incorporating breath holding and image guidance in the adjuvant gastric cancer radiotherapy: a dosimetric study. / Radiat Oncol 2012, 7:98. CrossRef
  88. Li W, Moseley DJ, Bissonnette JP, Purdie TG, Bezjak A, Jaffray DA: Setup reproducibility for thoracic and upper gastrointestinal radiation therapy: Influence of immobilization method and on-line cone-beam CT guidance. / Medical dosimetry: official journal of the American Association of Medical Dosimetrists 2010, 35:287-96.
  89. Dawson LA, Jaffray DA: Advances in image-guided radiation therapy. / J Clin Oncol 2007, 25:938-46. CrossRef
  90. Fuss M, Salter BJ, Cavanaugh SX, Fuss C, Sadeghi A, Fuller CD, Ameduri A, Hevezi JM, Herman TS, Thomas CR Jr: Daily ultrasound-based image-guided targeting for radiotherapy of upper abdominal malignancies. / Int J Radiat Oncol Biol Phys 2004, 59:1245-256. CrossRef
  91. Boda-Heggemann J, Guckenberger M, Ganswindt U, Belka C, Wertz H, Blessing M, Wenz F, Fuss M, Lohr F: [Image-guided radiation therapy]. / Radiologe 2012, 52:213-21. CrossRef
  92. Boda-Heggemann J, Lohr F, Wenz F, Flentje M, Guckenberger M: kV cone-beam CT-based IGRT: a clinical review. / Strahlenther Onkol 2011, 187:284-91. CrossRef
  93. Boda-Heggemann J, Mennemeyer P, Wertz H, Riesenacker N, Kupper B, Lohr F, Wenz F: Accuracy of ultrasound-based image guidance for daily positioning of the upper abdomen: an online comparison with cone beam CT. / Int J Radiat Oncol Biol Phys 2009, 74:892-97. CrossRef
  94. Welsh J, Gomez D, Palmer MB, Riley BA, Mayankkumar AV, Komaki R, Dong L, Zhu XR, Likhacheva A, Liao Z, / et al.: Intensity-modulated proton therapy further reduces normal tissue exposure during definitive therapy for locally advanced distal esophageal tumors: a dosimetric study. / Int J Radiat Oncol Biol Phys 2011, 81:1336-342. CrossRef
  95. Boda-Heggemann J, Hofheinz RD, Weiss C, Mennemeyer P, Mai SK, Hermes P, Wertz H, Post S, Massner B, Hieber U, / et al.: Combined adjuvant radiochemotherapy with IMRT/XELOX improves outcome with low renal toxicity in gastric cancer. / Int J Radiat Oncol Biol Phys 2009, 75:1187-195. CrossRef
  96. Minn AY, Hsu A, La T, Kunz P, Fisher GA, Ford JM, Norton JA, Visser B, Goodman KA, Koong AC, Chang DT: Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. / Cancer 2010, 116:3943-952. CrossRef
  97. Hofheinz RD, Wenz F, Lukan N, Mai S, Kripp M, Staiger W, Schwarzbach M, Willeke F, Mohler M, Post S, Hochhaus A: Oxaliplatin and capecitabine-based chemoradiotherapy for gastric cancer–an extended phase I MARGIT and AIO trial. / Int J Radiat Oncol Biol Phys 2009, 73:142-47. CrossRef
  98. Boda-Heggemann J, Weiss C, Schneider V, Hofheinz R, Haneder S, Michaely HJ, Wertz H, Post S, Hochhaus A, Wenz F, Lohr F: Adjuvante Radiochemotherapie mit IMRT/XELOX verbessert das Gesamt- und krankheitsfreie überleben des fortgeschrittenen Magenkarzinoms gegenüber 3DCRT/5FU-FA auch im Langzeit-Follow-up. / Strahlenther Onkol 2012,188(Sondernr. 1):V02-5.
  99. Lin SH, Wang L, Myles B, Thall PF, Hofstetter WL, Swisher SG, Ajani JA, Cox JD, Komaki R, Liao Z: Propensity Score-based Comparison of Long-term Outcomes With 3-Dimensional Conformal Radiotherapy vs Intensity-Modulated Radiotherapy for Esophageal Cancer. / Int J Radiat Oncol Biol Phys 2012. http://www.ncbi.nlm.nih.gov/pubmed?term=lin%20wang%20propensity%20score-based
  
• 作者单位：Daniel Buergy (1)
  Frank Lohr (1)
  Tobias Baack (1)
  Kerstin Siebenlist (1)
  Stefan Haneder (2)
  Henrik Michaely (2)
  Frederik Wenz (1)
  Judit Boda-Heggemann (1)
  
  1. Department of Radiation Oncology, Universit?tsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  2. Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany
  

文摘

There is broad consensus on surgical resection being the backbone of curative therapy of gastric- and gastroesophageal junction carcinoma. Nevertheless, details on therapeutic approaches in addition to surgery, such as chemotherapy, radiotherapy or radiochemotherapy are discussed controversially; especially whether external beam radiotherapy should be applied in addition to chemotherapy and surgery is debated in both entities and differs widely between regions and centers. Early landmark trials such as the Intergroup-0116 and the MAGIC trial must be interpreted in the context of potentially insufficient lymph node resection. Despite shortcomings of both trials, benefits on overall survival by radiochemotherapy and adjuvant chemotherapy were confirmed in populations of D2-resected gastric cancer patients by Asian trials. Recent results on junctional carcinoma patients strongly suggest a survival benefit of neoadjuvant radiochemotherapy in curatively resectable patients. An effect of chemotherapy in the perioperative setting as given in the MAGIC study has been confirmed by the ACCORD07 trial for junctional carcinomas; however both the studies by Stahl et al. and the excellent outcome in the CROSS trial as compared to all other therapeutic approaches indicate a superiority of neoadjuvant radiochemotherapy as compared to perioperative chemotherapy in junctional carcinoma patients. Surgery alone without neoadjuvant or perioperative therapy is considered suboptimal in patients with locally advanced disease. In gastric carcinoma patients, perioperative chemotherapy has not been compared to adjuvant radiochemotherapy in a randomized setting. Nevertheless, the results of the recently published ARTIST trial and the Chinese data by Zhu and coworkers, indicate a superiority of adjuvant radiochemotherapy as compared to adjuvant chemotherapy in terms of disease free survival in Asian patients with advanced gastric carcinoma. The ongoing CRITICS trial is supposed to provide reliable conclusions about which therapy should be preferred in Western patients with gastric carcinoma. If radiotherapy is performed, modern approaches such as intensity-modulated radiotherapy and image guidance should be applied, as these methods reduce dose to organs at risk and provide a more homogenous coverage of planning target volumes.