Efficacy of gabapentin for prevention of postherpetic neuralgia: study protocol for a randomized controlled clinical trial

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• 作者：Manuel Rullán ; Oana Bulilete ; Alfonso Leiva ; Aina Soler ; Antonia Roca…
• 关键词：Postherpetic neuralgia ; Gabapentin ; Herpes zoster ; Prevention ; Primary health care
• 刊名：Trials
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：689KB
• 刊物主题：Medicine/Public Health, general; Biomedicine, general; Statistics for Life Sciences, Medicine, Health Sciences;
• 出版者：BioMed Central
• ISSN：1745-6215
• 卷排序：18

文摘

BackgroundPostherpetic neuralgia (PHN) is a chronic neuropathic pain that results from alterations of the peripheral nervous system in areas affected by the herpes zoster virus. The symptoms include pain, paresthesia, dysesthesia, hyperalgesia, and allodynia. Despite the availability of pharmacological treatments to control these symptoms, no treatments are available to control the underlying pathophysiology responsible for this disabling condition.