Imaging spectrum of sporadic cerebral amyloid angiopathy: multifaceted features of a single pathological condition

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• 作者：Keita Sakurai (1)
  Aya M. Tokumaru (1)
  Tomoya Nakatsuka (2)
  Shigeo Murayama (3)
  Shin Hasebe (1)
  Etsuko Imabayashi (1)
  Kazutomi Kanemaru (4)
  Masaki Takao (3)
  Hiroyuki Hatsuta (3)
  Kenji Ishii (5)
  Yuko Saito (6)
  Yuta Shibamoto (7)
  Noriyuki Matsukawa (8)
  Emiko Chikui (9)
  Hitoshi Terada (2)
  
• 关键词：Cerebral amyloid angiopathy ; Imaging ; Subarachnoid haemorrhage ; Microbleed ; Superficial siderosis ; CAA ; related inflammation
• 刊名：Insights into Imaging
• 出版年：2014
• 出版时间：June 2014
• 年：2014
• 卷：5
• 期：3
• 页码：375-385
• 全文大小：
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• 作者单位：Keita Sakurai (1)
  Aya M. Tokumaru (1)
  Tomoya Nakatsuka (2)
  Shigeo Murayama (3)
  Shin Hasebe (1)
  Etsuko Imabayashi (1)
  Kazutomi Kanemaru (4)
  Masaki Takao (3)
  Hiroyuki Hatsuta (3)
  Kenji Ishii (5)
  Yuko Saito (6)
  Yuta Shibamoto (7)
  Noriyuki Matsukawa (8)
  Emiko Chikui (9)
  Hitoshi Terada (2)
  
  1. Department of Diagnostic Radiology, Tokyo Metropolitan Medical Centre of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan
  2. Department of Radiology, Toho University Sakura Medical Centre, Sakura, Japan
  3. Department of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
  4. Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
  5. Positron Medical Centre, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
  6. Department of Pathology and Laboratory Medicine, National Centre for Neurology and Psychiatry Hospital, Tokyo, Japan
  7. Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  8. Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
  9. Department of Neurosurgery, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan
  
• ISSN：1869-4101

文摘

Objectives Sporadic cerebral amyloid angiopathy (CAA) is common cause of cerebrovascular disorders that predominantly affect elderly patients. When symptomatic, cortical-subcortical intracerebral haemorrhage (ICH) in the elderly is the most well-known manifestation of CAA. Furthermore, the clinical presentation varies from a sudden neurological deficit to seizures, transient symptoms and acute progressive cognitive decline. Despite its clinical importance, this multifaceted nature poses a diagnostic challenge for radiologists. The aims of this study were to expound the characteristics of neuroimaging modalities, which cover a wide spectrum of CAA-related imaging findings, and to review the various abnormal findings for which CAA could be responsible. Conclusions Radiologically, in addition to typical ICH, CAA leads to various types of abnormal findings, including microbleed, subarachnoid haemorrhage, superficial siderosis, microinfarction, reversible oedema, and irreversible leukoaraiosis. Taking into consideration the clinical importance of CAA-related disorders such as haemorrhagic risks and treatable oedema, it is necessary for radiologists to understand the wide spectrum of CAA-related imaging findings. Teaching Points -To describe the characteristics of imaging modalities and findings of CAA-related disorders. -MRI, especially gradient echo sequences, provides the useful information of CAA-related haemosiderin depositions. -To understand the wide spectrum of CAA-related neuroimaging and clinical features is important.