Immunoadsorption of Alloantibodies onto Erythroid Membrane Antigens Encapsulated into Polymeric Microparticles

详细信息    查看全文

• 作者：Val¨¦rie Hoffart ; Philippe Maincent ; Alf Lamprecht ; V¨¦ronique Latger-Cannard ; V¨¦ronique Regnault ; Christian Merle ; Val¨¦rie Jouan-Hureaux ; Thomas Lecompte ; Claude Vigneron and Nathalie Ubrich
• 关键词：alloantibodies ; biomaterials ; immunoadsorption ; microparticles ; red blood cell antigens
• 刊名：Pharmaceutical Research
• 出版年：2007
• 出版时间：November, 2007
• 年：2007
• 卷：24
• 期：11
• 页码：2055-2062
• 全文大小：337 KB

文摘

Purpose Classical immunoadsorbents used for the removal of deleterious molecules in blood such as auto-antibodies are prepared by covalent coupling of antigens onto previously chemically activated supports. Such a chemical treatment may induce a potential toxicity which can be reduced if new immunoadsorbents are prepared by encapsulating erythrocytes-ghosts carrying antigens inside polymeric and porous microparticles.