Two-step phase transition via in situ hydrolysis of thermosensitive polymeric micelles with acid-labile core

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• 作者：Qianling Cui (1)
  Guizhi Shen (1)
  Feipeng Wu (1)
  Erjian Wang (1)
  
• 关键词：Stimuli ; responsive polymers ; Diblock copolymers ; Microstructure ; Hydrogen bonding ; Phase behavior
• 刊名：Colloid & Polymer Science
• 出版年：2013
• 出版时间：October 2013
• 年：2013
• 卷：291
• 期：10
• 页码：2469-2473
• 全文大小：178KB
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• 作者单位：Qianling Cui (1)
  Guizhi Shen (1)
  Feipeng Wu (1)
  Erjian Wang (1)
  
  1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, People鈥檚 Republic of China
  
• ISSN：1435-1536

文摘

This communication reports thermoresponsive diblock copolymer micelles composed of a hydrophilic poly(ethylene glycol) (PEG) shell with temperature-responsive functionality and an acid-labile, hydrophobic poly(N-acryloyl-2,2-dimethyl-1,3-oxazolidine) (PADMO) core. Because of the partial in situ hydrolysis of these micelles, an interesting two-step phase transition occurs, exhibiting two separate cloud points. This can be attributed to the dual characters displayed by poly(2-hydroxyethyl acrylamide) (PHEAM), the hydrolysis product of PADMO in an acid medium. The formation of hydrogen bonding between PEG and PHEAM enhances the hydrophobicity of PEG chains and promotes the phase transition that takes place at a lower temperature than before. On the other hand, generation of water-soluble PHEAM increases the hydrophilicity of the whole micelles and requires higher temperature that induces dehydration of these micelles. This finding could help us better understand the relationship between micellar microstructure and thermosensitive behaviors.