Multi-color light-emitting amphiphilic cellulose/conjugated polymers nanomicelles for tumor cell imaging

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• 作者：Haoquan Zhong ; Jinming Zhang ; Yanzhu Guo ; Lu Wang ; Wenjiao Ge ; Meiwan Chen…
• 关键词：Amphiphilic cellulose derivative ; Nanomicelles ; Fluorescent conjugated polymers ; Tumor cell imaging
• 刊名：Cellulose
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：24
• 期：2
• 页码：889-902
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Bioorganic Chemistry; Physical Chemistry; Organic Chemistry; Polymer Sciences;
• 出版者：Springer Netherlands
• ISSN：1572-882X
• 卷排序：24

文摘

Novel cellulose nanomicelles self-assembled from amphiphilic cellulose-graft-poly(p-dioxanone) (MCC-graft-PPDO) copolymer were used to encapsulate and disperse hydrophobic fluorescent conjugated polymers (FCPs) in water for tumor cell imaging. Three different conjugated polymers were employed to demonstrate the versatility of the cellulose nanomicelles, resulting in highly fluorescent and stable polymeric nanoparticles with different emission wavelengths across the visible spectrum. Owing to the size effect of cellulose nanomicelles, the incorporated conjugated polymers present red-shifted emission to low-energy sites, and the fluorescence self-quenching of conjugated polymers at high concentration can be greatly inhibited. The in vitro studies using the liver cancer Hep3B cells and the breast cancer MAD-MB-231 cells indicate these amphiphilic cellulose/FCPs nanomicelles have negligible cytotoxicity even at high concentration of up to 100 μg/mL. Moreover, the light-emitting micelles are successfully uptaken by the cancer cells and located at the cytoplasm of the cells, suggesting their great potential for tumor cell imaging and early detection of tumor cells.