Translational Control Mechanisms in Angiogenesis and Vascular Biology

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• 作者：Peng Yao (1)
  Sandeepa M. Eswarappa (1)
  Paul L. Fox (1)
  
  1. Department of Cellular and Molecular Medicine ; Cleveland Clinic Lerner Research Institute ; 9500 Euclid Avenue/NC10 ; Cleveland ; OH ; 44195 ; USA
  
• 关键词：Angiogenesis ; Atherosclerosis ; GAIT ; MicroRNA ; Translational control ; Vascular endothelial growth factor
• 刊名：Current Atherosclerosis Reports
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：17
• 期：5
• 全文大小：996 KB
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• 刊物主题：Angiology; Cardiology;
• 出版者：Springer US
• ISSN：1534-6242

文摘

Among the multiple modes of regulation of gene expression, translational control is arguably the least investigated and understood, and its role in vascular biology and pathobiology is not an exception. Here, we review recent studies that have revealed exciting translational regulatory phenomena and mechanisms involving novel RNA binding proteins and microRNA machinery in vascular biology. From these studies, the importance of translational regulation in angiogenesis, atherosclerosis, and blood pressure maintenance is beginning to emerge. We believe that the recent development of powerful techniques such as ribosome profiling and translating ribosome affinity purification (TRAP) will motivate and facilitate additional research in these areas.