Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

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• 作者：Tian Yu (1)
  John Bachman (2)
  Zhi-Chun Lai (1) (2) (3)
  
  1. Intercollege Graduate Degree Program in Molecular ; Cellular and Integrative Biosciences ; The Pennsylvania State University ; University Park ; PA ; 16802 ; USA
  2. Department of Biology ; The Pennsylvania State University ; University Park ; PA ; 16802 ; USA
  3. Department of Biochemistry and Molecular Biology ; The Pennsylvania State University ; University Park ; PA ; 16802 ; USA
  
• 关键词：LATS1 & LATS2 ; hippo signaling ; cancer genome ; human cancer
• 刊名：Protein & Cell
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：6
• 期：1
• 页码：6-11
• 全文大小：218 KB
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  21. Yu T, Bachman J, Lai ZC (2013) Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer. Genetics 195:1193鈥?196 CrossRef
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• 刊物主题：Biochemistry, general; Protein Science; Cell Biology; Stem Cells; Human Genetics; Developmental Biology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1674-8018

文摘

In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to address, especially for those from less understood putative new cancer genes. As a powerful approach, in silico bioinformatics analysis could efficiently sort out mutations that are predicted to damage gene function. Such an analysis of human large tumor suppressor genes, LATS1 and LATS2, has been carried out and the results support a role of hLATS1//2 as negative growth regulators and tumor suppressors.