Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway

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• 作者：Alan R. Watson MA ; MD ; MRCP (1)
  Janusz Jankowski MD ; PhD ; FRCP
  
• 刊名：Current Colorectal Cancer Reports
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：3
• 期：1
• 页码：3-9
• 全文大小：272KB
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• 作者单位：Alan R. Watson MA, MD, MRCP (1)
  Janusz Jankowski MD, PhD, FRCP
  
  1. Histopathology Unit, Cancer Research UK, 44, Lincoln’s Inn Fields, London, WC2A 3PX, UK
  

文摘

It was previously though that adenomas gave rise to colorectal cancers and that other polyps were harmless. Serrated polyps—hyperplastic polyps, serrated adenomas, and sessile serrated adenomas—show distinct patterns of genetic and epigentic mutation that suggest their role in an alternative pathway of colorectal cancer development. In parallel with these findings are improved demographic and histologic data that also indicate that a subset of serrated polyps are precursors of cancer.