Impaired baroreflex sensitivity in subjects with impaired glucose tolerance, but not isolated impaired fasting glucose

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• 作者：Jin-Shang Wu (1) (2)
  Feng-Hwa Lu (1) (2)
  Yi-Ching Yang (1) (2)
  Shei-Hsi Chang (3)
  Ying-Hsiang Huang (2)
  Jia-Jin Jason Chen (4)
  Chih-Jen Chang (1) (2)
  
• 关键词：Diabetes mellitus ; Impaired glucose tolerance ; Impaired fasting glucose ; Spontaneous baroreflex sensitivity ; Valsalva ratio
• 刊名：Acta Diabetologica
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：51
• 期：4
• 页码：535-541
• 全文大小：226 KB
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• 作者单位：Jin-Shang Wu (1) (2)
  Feng-Hwa Lu (1) (2)
  Yi-Ching Yang (1) (2)
  Shei-Hsi Chang (3)
  Ying-Hsiang Huang (2)
  Jia-Jin Jason Chen (4)
  Chih-Jen Chang (1) (2)
  
  1. Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
  2. Department of Family Medicine, National Cheng Kung University Hospital, 138, Sheng Li Road, Tainan, 70403, Taiwan, ROC
  3. Department of Information and Communication, Kun Shan University, Tainan, Taiwan, ROC
  4. Institute of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan, ROC
  
• ISSN：1432-5233

文摘

Impaired baroreflex sensitivity (BRS) is associated with adverse cardiovascular outcomes. There are currently no studies on BRS changes in subjects with different glycemic statuses, including normal glucose tolerance (NGT), isolated impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and newly diagnosed diabetes (NDD). The aim of this study was to investigate the effects of NDD, IGT and isolated IFG on BRS, based on a community-based data. A total of 768 subjects were classified as NGT (n?=?498), isolated IFG (n?=?61), IGT (n?=?126) and NDD (n?=?83). Spontaneous BRS was determined by the spectral α coefficient method, i.e., the square root of the ratio between the power of the RR interval and the power of systolic blood pressure in the LF frequency region (0.04-.15?Hz) after the subjects had rested in a supine position for 5?min. Valsalva ratio was calculated as the longest RR interval after release of the Valsalva maneuver, divided by the shortest RR interval during the maneuver. As compared with NGT subjects, NDD (p?=?0.039) and IGT (p?=?0.041) subjects had a reduced spontaneous BRS in multivariate analysis based on analysis of covariance. NDD subjects exhibited a lower Valsalva ratio than NGT subjects (p?=?0.043). However, there were no significant differences in spontaneous BRS and Valsalva ratio between subjects with isolated IFG and NGT. In conclusion, NDD and IGT subjects had an impaired BRS as compared to NGT subjects. However, reduced BRS was not apparent in subjects with isolated IFG.