Distinct Somatic Discrimination Reflected by Laser-Evoked Potentials Using Scalp EEG Leads

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• 作者：Jen-Jui Hsueh ; Jia-Jin Jason Chen…
• 关键词：Laser ; evoked potential (LEP) ; Pain ; Equivalent dipole ; Primary somatosensory cortex ; Secondary somatosensory cortex
• 刊名：Journal of Medical and Biological Engineering
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：36
• 期：4
• 页码：460-469
• 全文大小：1,410 KB
• 刊物类别：Biomedical Engineering; Cell Biology; Imaging / Radiology;
• 刊物主题：Biomedical Engineering; Cell Biology; Imaging / Radiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：2199-4757
• 卷排序：36

文摘

Discrimination is an important function in pain processing of the somatic cortex. The involvement of the somatic cortex has been studied using equivalent dipole analysis and neuroimaging, but the results are inconsistent. Scalp electroencephalography (EEG) can reflect functional changes of particular brain regions underneath a lead. However, the responses of EEG leads close to the somatic cortex in response to pain have not been systematically evaluated. The present study applied CO₂ laser stimulation to the dorsum of the left hand. Laser-evoked potentials (LEPs) of C4, T3, and T4 leads and pain ratings in response to four stimulus intensities were analyzed. LEPs started earlier at the C4 and T4 leads. The onset latency and peak latency of LEPs for C4 and T4 leads were the same. Only 10 of 22 subjects (45 %) presented equivalent current dipoles within the primary somatosensory or motor cortices. LEP amplitudes of these leads increased as stimulation intensity increased. The stimulus–response pattern of the C4 lead was highly correlated with pain rating. In contrast, an S-shaped stimulus–response curve was obtained for the T3 and T4 leads. The present study provides supporting evidence that particular scalp channels are able to reflect the functional characteristics of their underlying cortical areas. Our data strengthen the clinical application of somatic-cortex-related leads for pain discrimination.