White matter tracts for the trafficking of neural progenitor cells characterized by cellular MRI and immunohistology: the role of CXCL12/CXCR4 signaling

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• 作者：Chiao-Chi V. Chen ; Yi-Hua Hsu ; D. M. Jayaseema…
• 关键词：SDF ; CXCR4 ; Stem cell ; Migration ; Tropism ; White matter ; Neurogenesis ; Homing ; Directed migration
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：220
• 期：4
• 页码：2073-2085
• 全文大小：11,208 KB
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• 作者单位：Chiao-Chi V. Chen (1)
  Yi-Hua Hsu (1)
  D. M. Jayaseema (1)
  Jeou-Yuan Joanne Chen (1)
  Dueng-Yuan Hueng (2) (3)
  Chen Chang (1)
  
  1. N123, Institute of Biomedical Sciences, Academia Sinica, 128, Section?2, Academia Road, Nankang, Taipei, 11529, Taiwan
  2. Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Kung Road, Neihu, 11490, Taipei, Taiwan
  3. Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan
  
• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

White matter tracts are important for the trafficking of neural progenitor cells (NPCs) in both normal and pathological conditions, but the underlying mechanism is not clear. The directionality of white matter is advantageous for molecules or cells to distribute over a long distance, but this feature is unlikely solely responsible for efficient migration. The present study hypothesizes that the efficient migration of NPCs into white matter is under the influences of neurochemical attraction—CXCL12/CXCR4 signaling, a major mechanism underlying the targeted migration of NPCs. To test this view, the present study investigated the effects of CXCL12 administration into the corpus callosum (CC) on the migratory behavior of transplanted NPCs. A living animal tracking platform based on MRI and a magnetic cell labeling technique was employed. The NPCs were magnetically labeled and then transplanted at the right end of the CC. CXCL12 was infused continuously at the left end. Migration of NPCs was monitored repeatedly over a 7-day course using 3D gradient echo T2*-weighted imaging. It was found that, CXCL12 induced NPCs to migrate up to 1,881?μm from the graft whereas the spontaneous migration was mere 200?μm. CXCL12 induced migration that was nine times as efficient in the speed. The results indicate that the CXCL12/CXCR4 signaling may be a mechanism via which NPCs efficiently migrate along the white matter tracts. The study also presents a potential strategy for facilitating the targeted migration in NPC therapy for brain disorders.