The effect of parathyroidectomy on chronic constipation in patients affected by primary hyperparathyroidism

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• 作者：Jessica Pepe (1)
  Danilo Badiali (1)
  Ivano Biviano (1)
  Italo Nofroni (2)
  Elisabetta Romagnoli (1)
  Mirella Cilli (1)
  Sara Piemonte (1)
  Cristiana Cipriani (1)
  Luciano Colangelo (1)
  Salvatore Minisola (1)
  
• 关键词：Chronic constipation ; Primary hyperparathyroidism ; Parathyroidectomy ; Rome III criteria ; Bristol stool scale
• 刊名：Journal of Bone and Mineral Metabolism
• 出版年：2013
• 出版时间：November 2013
• 年：2013
• 卷：31
• 期：6
• 页码：690-694
• 全文大小：
• 作者单位：Jessica Pepe (1)
  Danilo Badiali (1)
  Ivano Biviano (1)
  Italo Nofroni (2)
  Elisabetta Romagnoli (1)
  Mirella Cilli (1)
  Sara Piemonte (1)
  Cristiana Cipriani (1)
  Luciano Colangelo (1)
  Salvatore Minisola (1)
  
  1. Department of Internal Medicine and Medical Disciplines, apienzaUniversity of Rome, Viale del Policlinico 155, 00161, Rome, Italy
  2. Department of Public Health and Infectious Diseases, apienzaUniversity of Rome, Rome, Italy
  
• ISSN：1435-5604

文摘

Primary hyperparathyroidism (PHPT) is usually associated with chronic constipation; however, its prevalence is not defined by standardized criteria. The aim of the study was to evaluate both the prevalence of chronic constipation, defined by the standardized Rome diagnostic criteria III (Rome III) in PHPT, and the effect of parathyroidectomy (PTx). Fifty postmenopausal PHPT patients and 50 sex- and age-matched controls were studied. Each patient underwent mineral metabolism biochemical evaluation and completed a questionnaire and a 2-week diary card about bowel habits. PHPT patients were reevaluated after 6months. According to Rome III, 40% of PHPT patients had chronic constipation compared with 12% of controls (p=0.0002). The only difference between constipated PHPT patients (group A, n=20) and those without constipation (group B, n=30) was higher mean PTH values (79.918.7ng/l vs. 65.426.0ng/l; p=0.03), which predicted the presence of constipation (p=0.004, OR 1.059, CI 1.011.059). Forty percent of PHPT patients had undergone PTx. In group A, constipation was resolved in 80% of patients after PTx compared to none of the same group who had not undergone PTx (p=0.0007). In group B, 17.6% of patients who had not undergone PTx became, after 6months, constipated. According to Rome III, a higher prevalence of chronic constipation in PHPT patients was observed compared with controls. PTH levels predicted constipation. A significant reduction of chronic constipation was reported following successful surgery.