T1-mapping for assessment of ischemia-induced acute kidney injury and prediction of chronic kidney disease in mice

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• 作者：Katja Hueper (1) (2)
  Matti Peperhove (1)
  Song Rong (3) (4)
  Jessica Gerstenberg (3)
  Michael Mengel (5)
  Martin Meier (2) (6)
  Marcel Gutberlet (1) (2)
  Susanne Tewes (1)
  Amelie Barrmeyer (1)
  Rongjun Chen (3) (7)
  Herman Haller (3)
  Frank Wacker (1) (2)
  Dagmar Hartung (1) (2)
  Faikah Gueler (3)
  
• 关键词：Magnetic Resonance Imaging ; T1 ; mapping ; Acute Kidney Injury ; Ischemia ; Reperfusion Injury ; Edema ; Chronic Kidney disease
• 刊名：European Radiology
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：24
• 期：9
• 页码：2252-2260
• 全文大小：7,114 KB
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• 作者单位：Katja Hueper (1) (2)
  Matti Peperhove (1)
  Song Rong (3) (4)
  Jessica Gerstenberg (3)
  Michael Mengel (5)
  Martin Meier (2) (6)
  Marcel Gutberlet (1) (2)
  Susanne Tewes (1)
  Amelie Barrmeyer (1)
  Rongjun Chen (3) (7)
  Herman Haller (3)
  Frank Wacker (1) (2)
  Dagmar Hartung (1) (2)
  Faikah Gueler (3)
  
  1. Department of Radiology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany
  2. REBIRTH Cluster of Excellence, Hannover Medical School, Hannover, Germany
  3. Department of Nephrology, Hannover Medical School, Hannover, Germany
  4. Laboratory of Organ Transplantation, Zunyi Medical College, Zunyi, China
  5. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada
  6. Institute for Animal Science, Hannover Medical School, Hannover, Germany
  7. The Kidney Disease Center of the First Affiliated Hospital, Zhejiang University, Hangzhou, China
  
• ISSN：1432-1084

文摘

Objectives To investigate whether T1-mapping allows assessment of acute kidney injury (AKI) and prediction of chronic kidney disease (CKD) in mice. Methods AKI was induced in C57Bl/6N mice by clamping of the right renal pedicle for 35?min (moderate AKI, n--6) or 45?min (severe AKI, n--3). Sham animals served as controls (n--). Renal histology was assessed in the acute (day 1-?day 7; d1-?d7) and chronic phase (d28) after AKI. Furthermore, longitudinal MRI-examinations (prior to until d28 after surgery) were performed using a 7-Tesla magnet. T1-maps were calculated from a fat-saturated echoplanar inversion recovery sequence, and mean and relative T1-relaxation times were determined. Results Renal histology showed severe tubular injury at d1-?d7 in both AKI groups, whereas, at d28, only animals with prolonged 45-min ischemia showed persistent signs of AKI. Following both AKI severities T1-values significantly increased and peaked at d7. T1-times in the contralateral kidney without AKI remained stable. At d7 relative T1-values in the outer stripe of the outer medulla were significantly higher after severe than after moderate AKI (138?±-?% vs. 121?±-?%, p--.001). T1-elevation persisted until d28 only after severe AKI. Already at d7 T1 in the outer stripe of the outer medulla correlated with kidney volume loss indicating CKD (r--.83). Conclusion T1-mapping non-invasively detects AKI severity in mice and predicts further outcome. Key Points -Renal T1-relaxation times are increased after ischemia-induced acute kidney injury. -Renal T1-values correlate with subsequent kidney volume loss. -T1-mapping detects the severity of acute kidney injury and predicts further outcome.