Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor

详细信息查看全文

作者：Elizabeth P Smith (1)
Kathleen Shanks (1)
Michael M Lipsky (2)
Louis J DeTolla (2)
Achsah D Keegan (1) (3) (4)
Svetlana P Chapoval (1) (3) (4)
刊名：BMC Immunology
出版年：2011
出版时间：December 2011
年：2011
卷：12
期：1
全文大小：3944KB
参考文献：1. Kumanogoh A, Kikutani H: Immune semaphorins: a new area of semaphorin research.strong> / J Cell Sci 2003, 116:strong>3463鈥?470. ss="external" href="http://dx.doi.org/10.1242/jcs.00674">CrossRef
2. Suzuki K, Kumanogoh A, Kikutani H: Semaphorins and their receptors in immune cell interactions.strong> / Nat Immunol 2008, 9:strong>17鈥?3. ss="external" href="http://dx.doi.org/10.1038/ni1553">CrossRef
3. Gautier G, de Saint-Vis B, Senechal B, Pin JJ, Bates EE, Caux C, Geissmann F, Garrone P: The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations.strong> / Am J Pathol 2006, 168:strong>453鈥?5. ss="external" href="http://dx.doi.org/10.2353/ajpath.2006.050288">CrossRef
4. Czopik AK, Bynoe MS, Palm N, Raine CS, Medzhitov R: Semaphorin 7A is a negative regulator of T cell responses.strong> / Immunity 2006, 24:strong>591鈥?00. ss="external" href="http://dx.doi.org/10.1016/j.immuni.2006.03.013">CrossRef
5. Kumanogoh A, Shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatsu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DV, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani H: Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.strong> / Immunity 2005, 22:strong>305鈥?16. ss="external" href="http://dx.doi.org/10.1016/j.immuni.2005.01.014">CrossRef
6. Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK: Tim-2 regulates T helper type 2 responses and autoimmunity.strong> / J Exp Med 2005, 202:strong>437鈥?44. ss="external" href="http://dx.doi.org/10.1084/jem.20050308">CrossRef
7. Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, Hori M: Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.strong> / EMBO J 2007, 26:strong>1373鈥?384. ss="external" href="http://dx.doi.org/10.1038/sj.emboj.7601589">CrossRef
8. Yukawa K, Tanaka T, Yoshida K, Takeuchi N, Ito T, Takamatsu H, Kikutani H, Kumanogoh A: Sema4A induces cell morphological changes through B-type plexin-mediated signaling.strong> / Int J Mol Med 2010, 25:strong>225鈥?30.
9. Delaire S, Elhabazi A, Bensussan A, Boumsell L: CD100 is a leukocyte semaphorin.strong> / Cell Mol Life Sci 1998, 54:strong>1265鈥?276. ss="external" href="http://dx.doi.org/10.1007/s000180050252">CrossRef
10. Kumanogoh A, Suzuki K, Ch'ng E, Watanabe C, Takegahara N, Ishida I, Sato T, Habu S, Yoshida K, Shi W, Kikutani H: Requirement for the lymphocyte semaphorin, CD100, in the induction of antigen-specific T cells and the maturation of dendritic cells.strong> / J Immunol 2002, 169:strong>1175鈥?181.
11. Chabbert-de Ponnat I, Marie-Cardine A, Pasterkamp RJ, Schiavon V, Tamagnone L, Thomasset N, Bensussan A, Boumsell L: Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively.strong> / Int Immunol 2005, 17:strong>439鈥?47. ss="external" href="http://dx.doi.org/10.1093/intimm/dxh224">CrossRef
12. Kumanogoh A, Kikutani H: Biological functions and signaling of transmembrane semaphorin, CD100/Sema4D.strong> / Cell Mol Life Sci 2004, 61:strong>292鈥?00. ss="external" href="http://dx.doi.org/10.1007/s00018-003-3257-7">CrossRef
13. Fazzari P, Penachioni J, Gianola S, Rossi F, Eickholt BJ, Maina F, Alexopoulou L, Sottile A, Comoglio PM, Flavell RA, Tamagnone L: Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.strong> / BMC Dev Bio 2007, 7:strong>55. ss="external" href="http://dx.doi.org/10.1186/1471-213X-7-55">CrossRef
14. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM: Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.strong> / Cell 1999, 99:strong>71鈥?0. ss="external" href="http://dx.doi.org/10.1016/S0092-8674(00)80063-X">CrossRef
15. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.strong> / Nat Med 2004, 10:strong>1095鈥?103. ss="external" href="http://dx.doi.org/10.1038/nm1105">CrossRef
16. Wang J, Homer RJ, Hong L, Cohn L, Lee CG, Jung S, Elias JA: IL-11 selectively inhibits aeroallergen induced pulmonary eosinophilia and Th2 cytokine production.strong> / J Immunol 2000, 165:strong>2222鈥?231.
17. Chapoval SP, Nabozny GH, Marietta EV, Raymond EL, Krco CJ, Andrews AG, David CS: Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice.strong> / J Clin Invest 1999, 103:strong>1707鈥?717. ss="external" href="http://dx.doi.org/10.1172/JCI6175">CrossRef
18. Kelly-Welch AE, Melo ME, Smith E, Ford AQ, Haudenschild C, Noben-Trauth N, Keegan AD: Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation.strong> / J Immunol 2004, 172:strong>4545鈥?555.
19. Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA: Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.strong> / Clin Immunol 2009, 132:strong>371鈥?84. ss="external" href="http://dx.doi.org/10.1016/j.clim.2009.05.016">CrossRef
20. Chapoval SP, Al-Garawi A, Lora JM, Strickland I, Ma B, Lee PJ, Homer RJ, Ghosh S, Coyle AJ, Elias JA: Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.strong> / J Immunol 2007, 179:strong>7030鈥?041.
21. Wang H, Peters N, Laza-Stanca V, Nawroly N, Johnston SL, Schwarze J: Local CD11c+ MHC class II- precursors generate lung dendritic cells during respiratory viral infection, but are depleted in the process.strong> / J Immunol 2006, 177:strong>2536鈥?542.
22. Landsman L, Jung S: Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages.strong> / J Immunol 2007, 179:strong>3488鈥?494.
23. Wang X, Kumanogoh A, Watanabe C, Shi W, Yoshida K, Kikutani H: Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses.strong> / Blood 2001, 97:strong>3498鈥?504. ss="external" href="http://dx.doi.org/10.1182/blood.V97.11.3498">CrossRef
24. Nakano H, Yanagita M, Gunn MD: CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells.strong> / J Exp Med 2001, 194:strong>1171鈥?178. ss="external" href="http://dx.doi.org/10.1084/jem.194.8.1171">CrossRef
25. Hochweller K, Miloud T, Striegler J, Naik S, H盲mmerling GJ, Garbi N: Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop.strong> / Blood 2009, 114:strong>4411鈥?421. ss="external" href="http://dx.doi.org/10.1182/blood-2008-11-188045">CrossRef
26. Debbabi H, Ghosh S, Kamath AB, Alt J, Demello DE, Dunsmore S, Behar SM: Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells.strong> / Am J Physiol Lung Cell Mol Physiol 2005, 289:strong>L274-L279. ss="external" href="http://dx.doi.org/10.1152/ajplung.00004.2005">CrossRef
27. Radsak M, Iking-Konert C, Stegmaier S, Andrassy K, Hansch GM: Polymorphonuclear neutrophils as accessory cells for T-cell activation: major histocompatibility complex class II restricted antigen-dependent induction of T-cell proliferation.strong> / Immunology 2000, 101:strong>521鈥?30. ss="external" href="http://dx.doi.org/10.1046/j.1365-2567.2000.00140.x">CrossRef
28. Hogaboam CM, Lukacs NW, Chensue SW, Strieter RM, Kunkel SL: Monocyte chemoattractant protein-1 synthesis by murine lung fibroblasts modulates CD4+ T cell activation.strong> / J Immunol 1998, 160:strong>4606鈥?614.
29. Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA: Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation.strong> / J Immunol 2009, 182:strong>4686鈥?695. ss="external" href="http://dx.doi.org/10.4049/jimmunol.0803180">CrossRef
30. Roodink I, Verrijp K, Raats J, Leenders WP: Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies.strong> / BMC Cancer 2009, 9:strong>297. ss="external" href="http://dx.doi.org/10.1186/1471-2407-9-297">CrossRef
31. Basile JR, Castilho RM, Williams VP, Gutkind JS: Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.strong> / Proc Natl Acad Sci USA 2006, 103:strong>9017鈥?022. ss="external" href="http://dx.doi.org/10.1073/pnas.0508825103">CrossRef
32. Kumanogoh A, Marukawa S, Suzuki K, Takegahara N, Watanabe C, Ch'ng E, Ishida I, Fujimura H, Sakoda S, Yoshida K, Kikutani H: Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.strong> / Nature 2002, 419:strong>629鈥?33. ss="external" href="http://dx.doi.org/10.1038/nature01037">CrossRef
33. Lambrecht BN, Salomon B, Klatzmann D, Pauwels RA: Dendritic cells are required for the development of chronic eosinophilic airway inflammation in response to inhaled antigen in sensitized mice.strong> / J Immunol 1998, 160:strong>4090鈥?097.
34. van Rijt LS, Jung S, KleinJan A, Vos N, Willart M, Duez C, Hoogsteden HC, Lambrecht BN: In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma.strong> / J Exp Med 2005, 201:strong>981鈥?91. ss="external" href="http://dx.doi.org/10.1084/jem.20042311">CrossRef
35. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H: Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.strong> / Immunity 2000, 13:strong>621鈥?1. ss="external" href="http://dx.doi.org/10.1016/S1074-7613(00)00062-5">CrossRef
作者单位：Elizabeth P Smith (1)
Kathleen Shanks (1)
Michael M Lipsky (2)
Louis J DeTolla (2)
Achsah D Keegan (1) (3) (4)
Svetlana P Chapoval (1) (3) (4)

1. Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore St., Baltimore, Maryland, 21201, USA
2. Department of Pathology, University of Maryland School of Medicine, 10 South Pine St., MSTF, Baltimore, Maryland, 21201, USA
3. Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore St., HSF-I, Suite 380, Baltimore, Maryland, 21201, USA
4. Program in Oncology, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, 22 South Greene St., Baltimore, Maryland, 21201, USA
ISSN：1471-2172

文摘

Background Semaphorins were originally identified as molecules regulating a functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins found to be expressed on immune cells and were termed "immune semaphorins". It is known that Sema4A and Sema4D bind Tim-2 and CD72 expressed on leukocytes and PlexinD1 and B1 present on non-immune cells. These neuroimmune semaphorins and their receptors have been shown to play critical roles in many physiological and pathological processes including neuronal development, immune response regulation, cancer, autoimmune, cardiovascular, renal, and infectious diseases. However, the expression and regulation of Sema4A, Sema4D, and their receptors in normal and allergic lungs is undefined. Results Allergen treatment and lung-specific vascular endothelial growth factor (VEGF) expression induced asthma-like pathologies in the murine lungs. These experimental models of allergic airway inflammation were used for the expression analysis of immune semaphorins and their receptors employing immunohistochemistry and flow cytometry techniques. We found that besides accessory-like cells, Sema4A was also detected on bronchial epithelial and smooth muscle cells, whereas Sema4D expression was high on immune cells such as T and B lymphocytes. Surprisingly, under inflammation various cell types including macrophages, lymphocytes, and granulocytes in the lung expressed Tim-2, a previously defined marker for Th2 cells. CD72 was found on lung immune, inflammatory, and epithelial cells. Bronchial epithelial cells were positive for both plexins, whereas some endothelial cells selectively expressed Plexin D1. Plexin B1 expression was also detected on lung DC. Both allergen and VEGF upregulated the expression of neuroimmune semaphorins and their receptors in the lung tissue. However, the lung tissue Sema4A-Tim2 expression was rather weak, whereas Sema4D-CD72 ligand-receptor pair was vastly upregulated by allergen. Soluble Sema4D protein was present in the lung lysates and a whole Sema4A protein plus its dimer were readily detected in the bronchoalveolar (BAL) fluids under inflammation. Conclusions This study clearly shows that neuroimmune semaphorins Sema4A and Sema4D and their receptors might serve as potential markers for the allergic airway inflammatory diseases. Our current findings pave the way for further investigations of the role of immune semaphorins in inflammation and their use as potential therapeutic targets for the inflammatory lung conditions.