Identification of acetyltransferase genes (HAT1 and KAT8) regulating HBV replication by RNAi screening

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• 作者：Hui Wang ; KeHui Liu ; Bernard A. M. Fang ; HaiQing Wu ; FengDi Li…
• 关键词：KAT8 ; HAT1 ; HBV replication ; pgRNA ; RNAi screening
• 刊名：Cell & Bioscience
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：5
• 期：1
• 全文大小：1,001 KB
• 刊物主题：Cell Biology; Microbiology;
• 出版者：BioMed Central
• ISSN：2045-3701

文摘

Background The initiation of hepatitis B virus (HBV) replication involves the formation of covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei. The regulatory mechanism of HBV replication by acetyltransferase is thus far not well understood, but human acetyltransferase has been reported as being involved in the regulation of HBV replication.