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Polypyridyl iron(II) complexes showing remarkable photocytotoxicity in visible light
- 作者:ADITYA GARAI ; UTTARA BASU ; ILA PANT ; PATURU KONDAIAH…
- 关键词:Iron ; polypyridyl bases ; DNA binding ; photocytotoxicity ; apoptosis
- 刊名:Journal of Chemical Sciences
- 出版年:2015
- 出版时间:April 2015
- 年:2015
- 卷:127
- 期:4
- 页码:609-618
- 全文大小:987 KB
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- 作者单位:ADITYA GARAI (1)
UTTARA BASU (1) ILA PANT (2) PATURU KONDAIAH (2) AKHIL R CHAKRAVARTY (1)
1. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, 560012, India 2. Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, 560012, India
- 刊物类别:Chemistry and Materials Science
- 刊物主题:Chemistry
Chemistry
- 出版者:Springer India
- ISSN:0973-7103
文摘
Iron(II) complexes of polypyridyl ligands (B), viz. [Fe(B)2]Cl2 (1 and 2) of N, N, N-donor 2-(2-pyridyl)-1,10-phenanthroline (pyphen in 1) and 3-(pyridin-2-yl)dipyrido[3,2-a:2-3-c]phenazine (pydppz in 2), are prepared and characterized. They are 1:2 electrolytes in aqueous DMF. The diamagnetic complexes exhibit metal to ligand charge transfer band near 570 nm in DMF. The complexes are avid binders to calf thymus DNA giving binding constant (K b) values of ?06 M? suggesting significant intercalative DNA binding of the complexes due to presence of planar phenanthroline bases. Complex 2 exhibits significant photocytotoxicity in immortalized human keratinocyte cells HaCaT and breast cancer cell line MCF-7 giving IC50 values of 0.08 and 13 μM in visible light (400-00 nm). Complex 2 shows only minor dark toxicity in HaCaT cells but is non-toxic in dark in MCF-7 cancer cells. The light-induced cellular damage follows apoptotic pathway on generation of reactive oxygen species as evidenced from the dichlorofluorescein diacetate (DCFDA) assay.
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