Imaging changes associated with cognitive abnormalities in Parkinson’s disease

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• 作者：Yuko Koshimori ; Barbara Segura ; Leigh Christopher…
• 关键词：Parkinson’s disease ; Cognition ; Executive dysfunction ; Cortical thickness ; White matter ; Diffusion tensor imaging
• 刊名：Brain Structure and Function
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：220
• 期：4
• 页码：2249-2261
• 全文大小：955 KB
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• 作者单位：Yuko Koshimori (2) (3)
  Barbara Segura (3) (5)
  Leigh Christopher (2) (3)
  Nancy Lobaugh (3)
  Sarah Duff-Canning (1) (6)
  Romina Mizrahi (3)
  Clement Hamani (4)
  Anthony E. Lang (1)
  Kelly Aminian (2) (3)
  Sylvain Houle (3)
  Antonio P. Strafella (1) (2) (3) (7)
  
  2. Division of Brain, Imaging and Behaviour–Systems Neuroscience, Toronto Western Research Institute, UHN, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada
  3. Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), University of Toronto, 250 College St, Toronto, ON, M5T 1R8, Canada
  5. Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Casanova 146, 08035, Barcelona, Spain
  1. Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada
  6. Department of Neuropsychology, Toronto Western Hospital, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada
  4. Division of Neurosurgery, Toronto Western Hospital, UHN, University of Toronto, 399 Bathurst St, Toronto, ON, M5T 2S8, Canada
  7. Toronto Western Hospital and Institute, CAMH-Research Imaging Centre, University of Toronto, Toronto, ON, Canada
  
• 刊物主题：Neurosciences; Cell Biology; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1863-2661

文摘

The current study investigates both gray and white matter changes in non-demented Parkinson’s disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre- and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.