CCL15 overexpression predicts poor prognosis for hepatocellular carcinoma

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• 作者：YueGuo Li ; Hai Peng Yu ; Peng Zhang
• 关键词：Hepatocellular carcinoma ; CCL15 ; Immunohistochemistry ; Survival time
• 刊名：Hepatology International
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：10
• 期：3
• 页码：488-492
• 全文大小：614 KB
• 参考文献：1.Zhang Y, Fan Y, Mei Z. NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification. Cancer Epidemiol. 2012;36(5):e294–9.CrossRef PubMed
  2.Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 2002;31:339–46.CrossRef PubMed
  3.Singh S, Sadanandam A, Singh RK. Chemokines in tumor angiogenesis and metastasis. Cancer Metastasis Rev. 2007;26:453–67.CrossRef PubMed PubMedCentral
  4.Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50–6.CrossRef PubMed
  5.Li Y, Wu J, Zhang W, et al. Identification of serum CCL15 in hepatocellular carcinoma. Br J Cancer. 2013;108(1):99–106.CrossRef PubMed PubMedCentral
  6.Youn BS, Zhang SM, Lee EK, et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J Immunol. 1997;159:5201–5.PubMed
  7.Hwang J, Kim CW, Son KN, et al. Angiogenic activity of human CC chemokine CCL15 in vitro and in vivo. FEBS Lett. 2004;570:47–51.CrossRef PubMed
  8.Pardigol A, Forssmann U, Zucht HD, et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. Proc Natl Acad Sci USA. 1998;95:6308–13.CrossRef PubMed PubMedCentral
  9.Ko J, Kim IS, Jang SW, et al. Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells. FEBS Lett. 2002;515:159–64.CrossRef PubMed
  10.Gerard C, Rollins BJ. Chemokines and disease. Nat Immunol. 2001;2:108–15.CrossRef PubMed
  11.Mukaida N. Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation. Int J Hematol. 2000;72:391–8.PubMed
  12.Kunz M, Hartmann A, Flory E, et al. Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. Am J Pathol. 1999;155:753–63.CrossRef PubMed PubMedCentral
  13.Desbaillets I, Diserens AC, Tribolet N, et al. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med. 1997;186:1201–12.CrossRef PubMed PubMedCentral
  14.Itatani Y, Kawada K, Fujishita T, et al. Loss of SMAD4 from colorectal cancer cells promotes CCL15 expression to recruit CCR1+ myeloid cells and facilitate liver metastasis. Gastroenterology. 2013;145(5):1064–75.CrossRef PubMed
  
• 作者单位：YueGuo Li (1)
  Hai Peng Yu (2)
  Peng Zhang (1)
  
  1. Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The National “863” Program of Clinical Research Laboratory, Tianjin, 300060, People’s Republic of China
  2. Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, The National “863” Program of Clinical Research Laboratory, Tianjin, 300060, People’s Republic of China
  
• 刊物主题：Hepatology; Colorectal Surgery; Surgery;
• 出版者：Springer India
• ISSN：1936-0541

文摘

Objectives The purpose of this study was to study the expression of CCL15 in hepatocellular carcinoma (HCC) and explore its clinicopathological significance, and study relationships between expressions of CCL15 and malignant behaviors of HCC.