Efficacy and toxicity of rechallenge with combination immune checkpoint blockade in metastatic melanoma: a case series

详细信息    查看全文

• 作者：Lavinia Spain ; Gerard Walls ; Christina Messiou…
• 关键词：Advanced melanoma ; Combination immune checkpoint therapy ; Ipilimumab ; Nivolumab ; Immune ; related toxicity
• 刊名：Cancer Immunology, Immunotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：1
• 页码：113-117
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Oncology; Immunology; Cancer Research;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0851
• 卷排序：66

文摘

BackgroundThe efficacy and potential toxicity of rechallenge with combination ipilimumab and nivolumab has not been described. Retreatment of patients with immune checkpoint inhibitors in the setting of prior significant toxicity lacks evidence-based guidance.