Total Synthesis of Lignan Lactone (--Hinokinin

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• 作者：Qi-Long Zhou ; Hui-Jing Wang ; Pei Tang ; Hao Song…
• 关键词：Lignan ; Hinokinin ; Total synthesis ; Cascade reaction
• 刊名：Natural Products and Bioprospecting
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：5
• 期：5
• 页码：255-261
• 全文大小：781 KB
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• 作者单位：Qi-Long Zhou (1)
  Hui-Jing Wang (1)
  Pei Tang (1)
  Hao Song (2)
  Yong Qin (2)
  
  1. Innovative Drug Research Centre, Chongqing University, Chongqing, 401331, China
  2. Key Laboratory of Drug Targeting and Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
  
• 刊物主题：Plant Biochemistry; Bioorganic Chemistry; Medicinal Chemistry; Pharmacology/Toxicology; Plant Sciences; Food Science;
• 出版者：Springer Berlin Heidelberg
• ISSN：2192-2209

文摘

This research paper is aimed at studying the total synthesis of pharmacologically active lignan (--hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate. Keywords Lignan Hinokinin Total synthesis Cascade reaction