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L’acide lysophosphatidique: un lien entre obésité et intolérance au glucose
- 作者:C. Rancoule (1)
R. Dusaulcy (1) C. Attané (2) (3) K. Tréguer (1) S. Grès (1) J. -S. Saulnier-Blache (1)
- 关键词:Obésité ; Homéostasie glucidique ; Insuline ; Acide lysophosphatidique ; Récepteurs ; Obesity ; Glucose homeostasis ; Insulin Lysophosphatidicacid ; Receptors
- 刊名:Ob篓娄sit篓娄
- 出版年:2013
- 出版时间:December 2013
- 年:2013
- 卷:8
- 期:4
- 页码:244-247
- 全文大小:93 KB
- 作者单位:C. Rancoule (1)
R. Dusaulcy (1) C. Attané (2) (3) K. Tréguer (1) S. Grès (1) J. -S. Saulnier-Blache (1)
1. Institut des maladies métaboliques et cardiovasculaires (I2MC), Inserm U1048, Université Paul Sabatier, Toulouse, France 2. Montreal Diabetes Research Center and CRCHUM, Montreal, QC, Canada 3. Institut des maladies métaboliques et cardiovasculaires (I2MC), Inserm U1048, 1, avenue Jean Poulhès, BP 84225, 31432, Toulouse cedex 4, France
- ISSN:1951-6002
文摘
Lysophosphatidicacid (LPA) is a lipid mediator acting through specific receptors (LPAR) and is synthesized by autotaxin (ATX), a secreted lysophospholipase D. ATX expression is increased in gluco-intolerant obese individuals. LPA inhibits adipogenesis and impairs glucose tolerance through inhibition of insulin secretion. In obesemice fed a high fat diet, invalidation ATX in adipocytes (FATX-KOmice), or treatment with a LPAR antagonist, enhance adipose tissue expansion while improving glucose and insulin tolerance. Thus, ATX and LPAR represent potential pharmacological targets to treat obesity-associated metabolic diseases.
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