GRO-α/CXCR2 System and ADAM17 Correlated Expression in Sj?gren’s Syndrome

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• 作者：Sabrina Lisi (1)
  Margherita Sisto (1)
  Dario Domenico Lofrumento (2)
  Massimo D’Amore (3)
  Raffaella De Lucro (1)
  Domenico Ribatti (1)
  
• 关键词：ADAM 17 ; TAPI ; 1 ; CXCR2 ; GRO ; α ; sj?gren′s syndrome
• 刊名：Inflammation
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：36
• 期：3
• 页码：759-766
• 全文大小：267KB
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• 作者单位：Sabrina Lisi (1)
  Margherita Sisto (1)
  Dario Domenico Lofrumento (2)
  Massimo D’Amore (3)
  Raffaella De Lucro (1)
  Domenico Ribatti (1)
  
  1. Department of Basic Medical Sciences, Section of Human Anatomy and Histology, Laboratory of Cell Biology, University of Bari Medical School, Bari, Italy
  2. Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy
  3. Interdisciplinary Department of Medicine, Section of Rheumatology, University of Bari Medical School, Bari, Italy
  
• ISSN：1573-2576

文摘

The chemokine GRO-α and its receptor CXCR2 are associated with the chronic inflammation in Sj?gren’s syndrome (SS). To better understand the molecular mechanisms by which the GRO-α/CXCR2 system is involved in the SS inflammatory condition, our studies were designed to clarify the role of ADAM17 activation in the modulation of the GRO-α/CXCR2 chemokine system in epithelial cells (SGEC) from SS salivary glands. The CXCR2 overexpression observed in SS SGEC was dramatically decreased by ADAM17 inhibitor TAPI-1. In addition, comparing the expression levels of ADAM17 in healthy SGEC in presence or not of GRO-α treatment, we observed that GRO-α dose-dependently influences ADAM17 activation, an effect that was inhibited by blocking the interaction of GRO-α with its CXCR2 receptor. Our data show for the first time that ADAM17 has an important role in GRO-α/CXCR2 system activity regulation, suggesting that regulating CXCR2/ADAM17 interaction could be an attractive therapeutic target in SS.