Understanding risk in the oldest old: Frailty and the metabolic syndrome in a Chinese community sample aged 90+ years
详细信息    查看全文
  • 作者：Q. Hao ; X. Song ; M. Yang ; Birong Dong…
  • 关键词：Deficit accumulation ; frailty index ; metabolic syndrome ; mortality ; frailty
  • 刊名：The journal of nutrition, health & aging
  • 出版年：2016
  • 出版时间：January 2016
  • 年：2016
  • 卷：20
  • 期：1
  • 页码：82-88
  • 全文大小：240 KB
  • 参考文献：1.Lewington S, Whitlock G et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 2007;370:1829–1839. doi: 10.1016/S0140-6736(07)61778-4.PubMed CrossRef
    2.Singh GM, Danaei G, Farzadfar F et al. The age-specific quantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis. PLoS One 2013;8:e65174. doi: 10.1371/journal.pone.0065174.PubMed PubMedCentral CrossRef
    3.Blom JW, de Ruijter W, Witteman JC et al. Changing prediction of mortality by systolic blood pressure with increasing age: the Rotterdam study. Age (Dordr) 2013;35:431–438. doi: 10.1007/s11357-011-9349-7.CrossRef
    4.Clegg A, Young J, Iliffe S et al. Frailty in elderly people. Lancet 2013;381:752–762. doi: 10.1016/S0140-6736(12)62167-9.PubMed CrossRef
    5.Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. CMAJ 2011;183:E487–E494. doi: 10.1503/cmaj.101271.PubMed PubMedCentral CrossRef
    6.Rockwood K, Rockwood MR, Mitnitski A. Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index. J Am Geriatr Soc 2010;58:318–323. doi: 10.1111/j.1532-5415.2009.02667.x.PubMed CrossRef
    7.Rockwood K. What would make a definations of frailty successful? Age Ageing 2005;34(5):432–434. doi: 10.1093/ageing/afi146.PubMed CrossRef
    8.Lehnert T, Heider D, Leicht H et al. Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev 2011;68:387–420. doi: 10.1177/1077558711399580.PubMed CrossRef
    9.Pizent A, Pavlovic M, Jurasovic J et al. Antioxidants, trace elements and metabolic syndrome in elderly subjects. J Nutr Health Aging 2010;14: 866–871.PubMed CrossRef
    10.Tang Z, Wang C, Song X et al. Co-occurrence of cardiometabolic diseases and frailty in older Chinese adults in the Beijing Longitudinal Study of Ageing. Age Ageing; 2013;42:346–351. doi: 10.1093/ageing/aft004.PubMed CrossRef
    11.Kalyani RR, Varadhan R, Weiss CO, Fried LP, Cappola AR. Frailty status and altered dynamics of circulating energy metabolism hormones after oral glucose in older women. J Nutr Health Aging. 2012;16(8):679–86 doi: 10.1007/s12603-012-0369-5.PubMed CrossRef
    12.Collerton J, Martin-Ruiz C, Davies K et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study. Mech Ageing Dev 2012;133:456–466. doi: 10.1016/j. mad.2012.05.005PubMed CrossRef
    13.Liu CL, Lin MH, Peng LN et al. Late-life metabolic syndrome prevents cognitive decline among older men aged 75 years and over: one-year prospective cohort study. J Nutr Health Aging 2013;17:523–526. doi: 10.1007/s12603-013-0010-2.PubMed CrossRef
    14.Hubbard RE, Lang IA, Llewellyn DJ et al. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci 2010;65:377–381. doi: 10.1177/0020764012437676PubMed CrossRef
    15.Blaum CS, Xue QL, Michelon E et al. The association between obesity and the frailty syndrome in older women: the Women’s Health and Aging Studies. J Am Geriatr Soc 2005;53:927–934. doi: 10.1111/j.1532-5415.2005.53300.x.PubMed CrossRef
    16.Chiang PH, Liu CL, Lin MH et al. Survival benefits of metabolic syndrome among older men aged 75 years and over in Taiwan. J Nutr Health Aging 2012;16:520–524.PubMed CrossRef
    17.Hu G, Qiao Q, Tuomilehto J et al. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med 2004;164:1066–1076. doi: 10.1001/archinte.164.10.1066.PubMed CrossRef
    18.Vischer UM, Safar ME, Safar H et al. Cardiometabolic determinants of mortality in a geriatric population: is there a reverse metabolic syndrome? Diabetes Metab 2009;35(2):108–14. doi:10.1016/j.diabet.2008.08.006.PubMed CrossRef
    19.Lewington S, Clarke R, Qizilbash N et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 2002;360:1903–1913. doi:10.1016/S0140-6736(02)11911-8.PubMed CrossRef
    20.Sattar N, McConnachie A, Shaper AG, et al. Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet 2008;371:1927–1935. doi: 10.1016/S0140-6736(08)60602-9.PubMed CrossRef
    21.Luo L, Yang M, Hao Q et al. Cross-sectional study examining the association between metabolic syndrome and cognitive function among the oldest old. J Am Med Dir Assoc 2013;14:105–108. doi: 10.1016/j.jamda.2012.10.001.PubMed CrossRef
    22.Searle SD, Mitnitski A, Gahbauer EA et al. A standard procedure for creating a frailty index. BMC Geriatr 2008;8:24. doi: 10.1186/1471-2318-8-24.PubMed PubMedCentral CrossRef
    23.Saum KU, Dieffenbach AK, Muller H et al. Frailty prevalence and 10-year survival in community-dwelling older adults: results from the ESTHER cohort study. Eur J Epidemiol 2014;29:171–9. doi: 10.1007/s10654-014-9891-6.PubMed CrossRef
    24.Yu P, Song X, Shi J et al. Frailty and survival of older Chinese adults in urban and rural areas: results from the Beijing Longitudinal Study of Aging. Arch Gerontol Geriatr 2012;54:3–8. doi: 10.1016/j.archger.2011.04.020.PubMed CrossRef
    25.Li GQ, Fan J, Liu J et al. Impact of cerebrovascular disease mortality on life expectancy in China. Biomed Environ Sci 2014;27:169–175. doi: 10.3967/bes2014.038.PubMed
    26.Lin F, Roiland R, Chen DG et al. Linking cognition and frailty in middle and old age: metabolic syndrome matters. Int J Geriatr Psychiatry, 2014. doi:10.1002/gps.4115.
    27.Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD, et al. Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch Intern Med. 2007 Apr 9;167(7):635–41.PubMed CrossRef
    28.Akbaraly TN, Ancelin ML, Jaussent I et al. Metabolic syndrome and onset of depressive symptoms in the elderly: findings from the three-city study. Diabetes Care 2011;34(4):904–9. doi:10.2337/dc10-1644.PubMed PubMedCentral CrossRef
    29.Carriere I, Peres K, Ancelin ML et al. Metabolic syndrome and disability: findings from the prospective three-city study. J Gerontol A Biol Sci Med Sci 2014;69(1):79–86. doi: 10.1093/gerona/glt101.PubMed PubMedCentral CrossRef
    30.Peterson MD, Al Snih S, Stoddard J et al. Obesity misclassification and the metabolic syndrome in adults with functional mobility impairments: Nutrition Examination Survey 2003-2006. Prev Med 2014;60:71–6. doi: 10.1016/j.ypmed.2013.12.014.PubMed PubMedCentral CrossRef
    31.Almeida OP, Calver J, Jamrozik K et al. Obesity and metabolic syndrome increase the risk of incident depression in older men: the health in men study. Am J Geriatr Psychiatry 2009;17(10):889–98. doi:10.1097/JGP.0b013e3181b047e3.PubMed CrossRef
    32.Levin BE, Llabre MM, Dong C et al. Modeling Metabolic Syndrome and Its Association with Cognition: The Northern Manhattan Study. J Int Neuropsychol Soc 2014;20(10):951–60. doi:10.1017/S1355617714000861.PubMed PubMedCentral CrossRef
    33.Abizanda P, Romero L, Sanchez-Jurado PM et al. Age, frailty, disability, institutionalization, multimorbidity or comorbidity. Which are the main targets in older adults? J Nutr Health Aging 2014;18(6):622–7. doi:10.1007/s12603-014-0033-3.PubMed CrossRef
    34.Ravaglia G, Morini P, Forti P et al. Anthropometric characteristics of healthy Italian nonagenarians and centenarians. Br J Nutr 1997;77(1):9–17.PubMed CrossRef
    35.Lisko I, Tiainen K, Stenholm S et al. Body mass index, waist circumference, and waist-to-hip ratio as predictors of mortality in nonagenarians: the Vitality 90+ Study. J Gerontol A Biol Sci Med Sci 2011;66(11):1244–50. doi:10.1093/gerona/glr147.PubMed CrossRef
    36.Upmeier E, Lavonius S, Heinonen P et al. Longitudinal changes in serum lipids in older people the Turku elderly study 1991-2006. Age Ageing 2011;40:280–283. doi: 10.1093/ageing/afq180.PubMed CrossRef
    37.Muller M, Smulders YM, de Leeuw PW et al. Treatment of hypertension in the oldest old: a critical role for frailty? Hypertension 2014;63(3):433–41. doi:10.1161/hypertensionaha.113.00911.PubMed CrossRef
    38.Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab 2008;7(6):476–84. doi:10.1016/j.cmet.2008.03.010.PubMed PubMedCentral CrossRef
    39.Bastos-Barbosa RG, Ferriolli E, Coelho EB et al. Association of frailty syndrome in the elderly with higher blood pressure and other cardiovascular risk factors. Am J Hypertens 2012;25:1156–1161. doi: 10.1038/ajh.2012.99.PubMed CrossRef
    40.Song X, Mitnitski A, Rockwood K. Nontraditional risk factors combine to predict Alzheimer disease and dementia. Neurology 2011;77:227–234. doi: 10.1212/WNL.0b013e318225c6bc.PubMed PubMedCentral CrossRef
    41.Fang X, Shi J, Song X et al. Frailty in relation to the risk of falls, fractures, and mortality in older Chinese adults: results from the Beijing Longitudinal Study of Aging. J Nutr Health Aging 2012;16(10):903–7. doi:10.1007/s12603-012-0368-6.PubMed CrossRef
    42.Wallace LM, Theou O, Kirkland SA et al. Accumulation of non-traditional risk factors for coronary heart disease is associated with incident coronary heart disease hospitalization and death. PLoS One 2014;9:e90475. doi: 10.1371/journal. pone.0090475.PubMed PubMedCentral CrossRef
    43.Kennedy CC, Ioannidis G, Rockwood K, et al. A Frailty Index predicts 10-year fracture risk in adults age 25 years and older: results from the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporos Int Aug 2014;8. doi: 10.1007/s00198-014-2828-9
    44.Fontana L, Kennedy BK, Longo VD, et al. Medical research: treat ageing. Nature 2014;511: 405–407. doi: 10.1038/511405a.PubMed CrossRef
    45.Addison O, Drummond MJ, LaStayo PC, Dibble LE, Wende AR, McClain DA, Marcus RL. Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity. J Nutr Health Aging. 2014;18(5):532–8 doi: 10.1007/s12603-014-0019-1.PubMed CrossRef
    46.Howlett SE, Rockwood MRH, Minitski A, Rockwood K. Standard laboratory tests to identify older adults at increased risk of death. BMC Med. 2014;12(1):171. doi: 10.1186/s12916-014-0171-9.PubMed PubMedCentral CrossRef
  • 作者单位：Q. Hao (1) (2)
    X. Song (2)
    M. Yang (1)
    Birong Dong (1)
    Kenneth Rockwood (2)

    1. The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
    2. Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
  • 刊物主题：Geriatrics/Gerontology; Nutrition; Aging; Neurosciences; Primary Care Medicine; Quality of Life Research;
  • 出版者：Springer Paris
  • ISSN：1760-4788
文摘
Objectives To investigate the relationship between frailty and the metabolic syndrome and to evaluate how these contribute to mortality in very old people.
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.