Gender differences in plasma and urine metabolites from Sprague–Dawley rats after oral administration of normal and high doses of hydroxytyrosol, hydroxytyrosol acetate, and DOPAC

详细信息    查看全文

• 作者：Raúl Domínguez-Perles ; David Auñón ; Federico Ferreres…
• 关键词：Hydroxytyrosol ; Hydroxytyrosol acetate ; DOPAC ; Oral administration ; Bioavailability ; Plasma ; Urine
• 刊名：European Journal of Nutrition
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：56
• 期：1
• 页码：215-224
• 全文大小：
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition;
• 出版者：Springer Berlin Heidelberg
• ISSN：1435-1293
• 卷排序：56

文摘

PurposeTo date, several in vitro and in vivo studies have shown phenolic compounds occurring naturally in olives and olive oil to be beneficial to human health due to their interaction with intracellular signaling pathways. However, the bioavailability of the most important of these compounds, hydroxytyrosol (HT), and its transformation into derivatives within the organism after oral intake are still not completely understood, requiring further in vivo research. This study deals with the differential bioavailability and metabolism of oral HT and its derivatives in rats.