Magnetic resonance imaging, computed tomography, and 68Ga-DOTATOC positron emission tomography for imaging skull base meningiomas with infracranial extension treated with stereotactic radiotherapy - a case series

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• 作者：Reinhold Graf (1)
  Michail Plotkin (2)
  Ingo G Steffen (2)
  Reinhard Wurm (3)
  Peter Wust (1)
  Winfried Brenner (2)
  Volker Budach (1)
  Harun Badakhshi (1)
  
• 关键词：Meningioma ; Skull Base ; 68Ga ; DOTATOC ; PET ; Stereotactic radiotherapy
• 刊名：Head & Face Medicine
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：8
• 期：1
• 全文大小：189KB
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• 作者单位：Reinhold Graf (1)
  Michail Plotkin (2)
  Ingo G Steffen (2)
  Reinhard Wurm (3)
  Peter Wust (1)
  Winfried Brenner (2)
  Volker Budach (1)
  Harun Badakhshi (1)
  
  1. Department of Radiation Oncology, Charité Universit?tsmedizin Berlin, Berlin, Germany
  2. Department of Nuclear Medicine, Charité Universit?tsmedizin Berlin, Berlin, Germany
  3. Department of Radiation Oncology, Klinikum Frankfurt (Oder), Kragujevac, Germany
  

文摘

Introduction Magnetic resonance imaging (MRI) and computed tomography (CT) with 68Ga-DOTATOC positron emission tomography (68Ga-DOTATOC-PET) were compared retrospectively for their ability to delineate infracranial extension of skull base (SB) meningiomas treated with fractionated stereotactic radiotherapy. Methods Fifty patients with 56 meningiomas of the SB underwent MRI, CT, and 68Ga-DOTATOC PET/CT prior to fractionated stereotactic radiotherapy. The study group consisted of 16 patients who had infracranial meningioma extension, visible on MRI ± CT (MRI/CT) or PET, and were evaluated further. The respective findings were reviewed independently, analyzed with respect to correlations, and compared with each other. Results Within the study group, SB transgression was associated with bony changes visible by CT in 14 patients (81%). Tumorous changes of the foramen ovale and rotundum were evident in 13 and 8 cases, respectively, which were accompanied by skeletal muscular invasion in 8 lesions. We analysed six designated anatomical sites of the SB in each of the 16 patients. Of the 96 sites, 42 had infiltration that was delineable by MRI/CT and PET in 35 cases and by PET only in 7 cases. The mean infracranial volume that was delineable in PET was 10.1 ± 10.6 cm3, which was somewhat larger than the volume detectable in MRI/CT (8.4 ± 7.9 cm3). Conclusions 68Ga-DOTATOC-PET allows detection and assessment of the extent of infracranial meningioma invasion. This method seems to be useful for planning fractionated stereotactic radiation when used in addition to conventional imaging modalities that are often inconclusive in the SB region.