Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy

详细信息    查看全文

• 作者：D. A. Savage ; C. C. Patterson ; P. Deloukas ; P. Whittaker ; A. J. McKnight ; J. Morrison ; A. J. Boulton ; A. G. Demaine ; S. M. Marshall and B. A. Millward ; et al.
• 关键词：Diabetic nephropathy ; Genetic association study ; Genetics of Kidneys in Diabetes ; Genetic susceptibility ; Non ; synonymous single nucleotide polymorphisms
• 刊名：Diabetologia
• 出版年：2008
• 出版时间：November, 2008
• 年：2008
• 卷：51
• 期：11
• 页码：1998-2002
• 全文大小：104.0 KB

文摘

Aims/hypothesis Diabetic nephropathy, characterised by persistent proteinuria, hypertension and progressive kidney failure, affects a subset of susceptible individuals with diabetes. It is also a leading cause of end-stage renal disease (ESRD). Non-synonymous (ns) single nucleotide polymorphisms (SNPs) have been reported to contribute to genetic susceptibility in both monogenic disorders and common complex diseases. The objective of this study was to investigate whether nsSNPs are involved in susceptibility to diabetic nephropathy using a case-control design.