Quantitative Analysis of [¹⁸F]FMISO PET for Tumor Hypoxia: Correlation of Modeling Results with Immunohistochemistry

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• 作者：Kuangyu Shi ; Christine Bayer ; Sabrina T. Astner…
• 关键词：Key wordsPharmacokinetic modeling ; Dynamic PET ; Fmiso ; Tumor hypoxia
• 刊名：Molecular Imaging and Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：19
• 期：1
• 页码：120-129
• 全文大小：
• 刊物主题：Imaging / Radiology;
• 出版者：Springer US
• ISSN：1860-2002
• 卷排序：19

文摘

PurposeQuantitative evaluation of tumor hypoxia based on H-1-(3-[18F]fluoro-2-hydroxypropyl)-2-nitroimidazole ([18F]FMISO) positron emission tomography (PET) can deliver important information for treatment planning in radiotherapy. However, the merits and limitations of different analysis methods in revealing the underlying physiological feature are not clear. This study aimed to assess these quantitative analysis methods with the support of immunohistological data.