Synthesis and characterization of curcumin segmented polyurethane with induced antiplatelet activity

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• 作者：Maryam Faghih Abdollahi ; Mojgan Zandi ; Parvin Shokrollahi…
• 关键词：Segmented polyurethane ; Curcumin ; Step ; growth polymerization ; Antiplatelet
• 刊名：Journal of Polymer Research
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：22
• 期：9
• 全文大小：2,105 KB
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• 作者单位：Maryam Faghih Abdollahi (1)
  Mojgan Zandi (2)
  Parvin Shokrollahi (2)
  Morteza Ehsani (1)
  
  1. Plastics Department, Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran
  2. Biomaterials Department, Iran Polymer and Petrochemical Institute, P.O. Box: 14965/115, Tehran, Iran
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Polymer Sciences
  Industrial Chemistry and Chemical Engineering
  Characterization and Evaluation Materials
  
• 出版者：Springer Netherlands
• ISSN：1572-8935

文摘

The main goal of this study is the synthesis of hemocompatible polyurethane elastomer containing curcumin by the reaction of poly(ξ-caprolactone) (PCL), and 1,6-hexamethylene diisocyanate (HDI), which was chain extended with varying molar ratios of 1,4-butandiol (BDO), and curcumin. Molecular structure of the synthesized polyurethane was confirmed using FT-IR and 1HNMR spectroscopy techniques. The effect of curcumin on characteristics of the synthesized polymers was analyzed by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), tensile testing, and also water contact angle measurement (WCA). The influence of curcumin on antiplatelet behavior of the curcumin extended elastomer was confirmed by static platelet adhesion (SPA) test and the number of the adhered platelets was determined using the lactate dehydrogenase (LDH) assay, in comparison with the polymer extended solely with BDO. Thermal and mechanical properties as well as hydrophobicity are enhanced through increasing curcumin content. Overall, improvement in mentioned properties led to enhanced antiplatelet behavior of curcumin containing segmented PU elastomers (PUcs).