Pax6 controls centriole maturation in cortical progenitors through Odf2

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• 作者：Marco A. Tylkowski (1) (2)
  Kefei Yang (3)
  Sigrid Hoyer-Fender (3)
  Anastassia Stoykova (1) (2)
  
  1. Research Group of Molecular Developmental Neurobiology ; Department Molecular Cell Biology ; Max-Planck Institute for Biophysical Chemistry ; Am Fa脽berg 11 ; 37077 ; G枚ttingen ; Germany
  2. Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) ; 37075 ; G枚ttingen ; Germany
  3. Johann-Friedrich-Blumenbach-Institute of Zoology and Anthropology ; Developmental Biology ; GZMB ; Ernst-Caspari-Haus ; Georg-August-Universit盲t G枚ttingen ; Justus-von-Liebig-Weg 11 ; G枚ttingen ; Germany
  
• 关键词：Centriole structure ; Transcriptional control
• 刊名：Cellular and Molecular Life Sciences (CMLS)
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：72
• 期：9
• 页码：1795-1809
• 全文大小：8,279 KB
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• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Biomedicine
  Life Sciences
  Biochemistry
  
• 出版者：Birkh盲user Basel
• ISSN：1420-9071

文摘

Cortical glutamatergic neurons are generated by radial glial cells (RGCs), specified by the expression of transcription factor (TF) Pax6, in the germinative zones of the dorsal telencephalon. Here, we demonstrate that Pax6 regulates the structural assembly of the interphase centrosomes. In the cortex of the Pax6-deficient Small eye (Sey/Sey) mutant, we find a defect of the appendages of the mother centrioles, indicating incomplete centrosome maturation. Consequently, RGCs fail to generate primary cilia, and instead of staying in the germinative zone for renewal, RGCs detach from the ventricular surface thus affecting the interkinetic nuclear migration and they exit prematurely from mitosis. Mechanistically, we show that TF Pax6 directly regulates the activity of the Odf2 gene encoding for the appendage-specific protein Odf2 with a role for the assembly of mother centriole. Our findings demonstrate a molecular mechanism that explains important characteristics of the centrosome disassembly and malfunctioning in developing cortex lacking Pax6.