Dissecting the regional diversity of glial cells by applying -omic technologies

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• 作者：Daniela C. Dieterich ; Moritz J. Rossner
• 关键词：Glial cell types ; Brain ; Transcriptomics ; Proteomics ; Cell isolation
• 刊名：e-Neuroforum
• 出版年：2015
• 出版时间：September 2015
• 年：2015
• 卷：6
• 期：3
• 页码：63-68
• 全文大小：652 KB
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• 作者单位：Daniela C. Dieterich (1) (2) (3)
  Moritz J. Rossner (4)
  
  1. Institute for Pharmacology and Toxicology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany
  2. Leibniz Institute for Neurobiology, 39118, Magdeburg, Germany
  3. Center for Behavioral Brain Sciences, Magdeburg, Germany
  4. Laboratory of Molecular and Behavioral Neurobiology, Department of Psychiatry, Nussbaumstr. 7, 80336, Munich, Germany
  
• 刊物主题：Neurosciences; Neurobiology; Life Sciences, general; Biomedicine general; Neurochemistry; Neurology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1868-856X

文摘

Neuronal as well as glial cells contribute to higher order brain functions. Many observations show that neurons and glial cells are not only physically highly intermingled but are physiologically tightly connected and mutually depend at various levels on each other. Moreover, macroglia classes like astrocytes, NG2 cells and oligodendrocytes are not at all homogenous cell populations but do possess a markedly heterogeneity in various aspects similar to neurons. The diversity of differences in morphology, functionality and, cellular activity has been acknowledged recently and will be integrated into a concept of brain function that pictures a neural rather than a puristical neuronal world. With the recent progress in “omic-technologies, an unbiased and exploratory approach toward an enhanced understanding of glial heterogeneity has become possible. Here, we provide an overview on current technical transcriptomic and proteomic approaches used to dissect glial heterogeneity of the brain. Keywords Glial cell types Brain Transcriptomics Proteomics Cell isolation