Cribriform-morular variant of papillary thyroid carcinoma: an indication to screen for occult FAP

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• 作者：Rachel A. Levy (1)
  Vanessa W. Hui (1)
  Rupa Sood (1)
  Stephanie Fish (2)
  Arnold J. Markowitz (3)
  Richard J. Wong (4)
  José G. Guillem (1)
  
• 关键词：Familial adenomatous polyposis ; Cribriform ; morular variant ; Papillary thyroid carcinoma ; Hereditary colorectal cancer
• 刊名：Familial Cancer
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：13
• 期：4
• 页码：547-551
• 全文大小：660 KB
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  4. Perrier ND, van Heerden JA, Goellner JR, Williams ED, Gharib H, Marchesa P, Church JM, Fazio VW, Larson DR (1998) Thyroid cancer in patients with familial adenomatous polyposis. World J Surg 22(7):738-42 discussion 743 CrossRef
  5. Giardiello FM, Offerhaus GJ, Lee DH, Krush AJ, Tersmette AC, Booker SV, Kelley NC, Hamilton SR (1993) Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut 34(10):1394-396 CrossRef
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  7. Bulow C, Bulow S (1997) Is screening for thyroid carcinoma indicated in familial adenomatous polyposis? The Leeds Castle polyposis group. Int J Colorectal Dis 12(4):240-42 CrossRef
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  11. Steinhagen E, Guillem JG, Chang G, Salo-Mullen EE, Shia J, Fish S, Stadler ZK, Markowitz AJ (2012) The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized. Clin Colorectal Cancer 11(4):304-08. doi:10.1016/j.clcc.2012.01.006 CrossRef
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  13. Steinhagen E, Hui VW, Levy RA, Markowitz AJ, Fish S, Wong RJ, Sood R, Ochman SM, Guillem JG (In press) Results of a prospective thyroid utrasound screening program in adenomatous polyposis patients. Am J Surg
  14. Crail HW (1949) Multiple primary malignancies arising in the rectum, brain, and thyroid; report of a case. US Nav Med Bull 49(1):123-28
  15. Tomoda C, Miyauchi A, Uruno T, Takamura Y, Ito Y, Miya A, Kobayashi K, Matsuzuka F, Kuma S, Kuma K, Kakudo K (2004) Cribriform-morular variant of papillary thyroid carcinoma: clue to early detection of familial ad
• 作者单位：Rachel A. Levy (1)
  Vanessa W. Hui (1)
  Rupa Sood (1)
  Stephanie Fish (2)
  Arnold J. Markowitz (3)
  Richard J. Wong (4)
  José G. Guillem (1)
  
  1. Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Room C-1077, New York, NY, 10065, USA
  2. Medicine/Endocrinology Service, New York, NY, USA
  3. Medicine/Gastroenterology and Nutrition Service, New York, NY, USA
  4. Surgery/Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
  
• ISSN：1573-7292

文摘

Cribriform-morular variant (CMV) is a rare subtype of papillary thyroid carcinoma (PTC) that is associated with familial adenomatous polyposis (FAP). Given the high likelihood for multi-organ malignancies in FAP patients, this study explores the yield of diagnosing occult FAP among CMV-PTC patients. Institutional database was searched in order to identify patients with pathologically-confirmed CMV-PTC from 2000 to 2012. Medical records were reviewed, and clinical and pathological features were analyzed. Eleven cases of CMV were identified from 6,901 patients with PTC, for a prevalence of 0.16?%. All 11 patients were female. The median age at CMV-PTC diagnosis was 36?years (range 18-6). Two patients had pre-existing FAP at the time of PTC diagnosis. The other nine patients were referred for colonoscopy and/or genetic testing. Six patients underwent colonoscopy and one (17?%) was diagnosed with FAP based on polyposis phenotype and genetic testing. The mean age of patients at the time of CMV-PTC diagnosis was younger in the FAP group (23?years, range 18-4) than in the sporadic group (37?years, range 25-6). All three patients with FAP-associated CMV-PTC had multicentric tumors, while all five sporadic patients did not. Our study found that approximately one-sixth of patients with CMV-PTC may have occult FAP. Patients with FAP-associated CMV-PTC appear to be younger and more likely to have multicentric tumors than those with sporadic CMV-PTC. Due to the increased risk of malignancy in patients with FAP, patients with CMV-PTC should be referred for colonoscopy and/or genetic evaluation for FAP.